[HTML][HTML] MicroRNA: A signature for cancer progression
MicroRNAs (miRNAs) are a group of small non-coding RNAs that post-transcriptionally
control expression of genes by targeting mRNAs. miRNA alterations partake in the …
control expression of genes by targeting mRNAs. miRNA alterations partake in the …
MicroRNAs as regulatory elements in immune system logic
A Mehta, D Baltimore - Nature Reviews Immunology, 2016 - nature.com
MicroRNAs (miRNAs) are crucial post-transcriptional regulators of haematopoietic cell fate
decisions. They act by negatively regulating the expression of key immune development …
decisions. They act by negatively regulating the expression of key immune development …
MicroRNAs: history, biogenesis, and their evolving role in animal development and disease
M Bhaskaran, M Mohan - Veterinary pathology, 2014 - journals.sagepub.com
The discovery of microRNAs (miRNAs) in 1993 followed by developments and discoveries
in small RNA biology have redefined the biological landscape by significantly altering the …
in small RNA biology have redefined the biological landscape by significantly altering the …
MicroRNAs in the p53 network: micromanagement of tumour suppression
H Hermeking - Nature reviews cancer, 2012 - nature.com
In recent years, microRNAs (miRNAs) have been identified as mediators of tumour
suppression and stress responses exerted by the p53 tumour suppressor. p53-regulated …
suppression and stress responses exerted by the p53 tumour suppressor. p53-regulated …
miR-99a/100∼ 125b tricistrons regulate hematopoietic stem and progenitor cell homeostasis by shifting the balance between TGFβ and Wnt signaling
S Emmrich, M Rasche, J Schöning… - Genes & …, 2014 - genesdev.cshlp.org
Although regulation of stem cell homeostasis by microRNAs (miRNAs) is well studied, it is
unclear how individual miRNAs genomically encoded within an organized polycistron can …
unclear how individual miRNAs genomically encoded within an organized polycistron can …
Myelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutations
Recurrent mutations in the gene encoding additional sex combs-like 1 (ASXL1) are found in
various hematologic malignancies and associated with poor prognosis. In particular, ASXL1 …
various hematologic malignancies and associated with poor prognosis. In particular, ASXL1 …
Dysfunction of the TP53 tumor suppressor gene in lymphoid malignancies
ZY Xu-Monette, LJ Medeiros, Y Li… - Blood, The Journal …, 2012 - ashpublications.org
Mutations of the TP53 gene and dysregulation of the TP53 pathway are important in the
pathogenesis of many human cancers, including lymphomas. Tumor suppression by p53 …
pathogenesis of many human cancers, including lymphomas. Tumor suppression by p53 …
Good guy or bad guy: the opposing roles of microRNA 125b in cancer
J Banzhaf-Strathmann, D Edbauer - Cell communication and signaling, 2014 - Springer
MicroRNAs (miRNAs) are a class of non-coding RNAs that post-transcriptionally silence
target mRNAs. Dysregulation of miRNAs is a frequent event in several diseases, including …
target mRNAs. Dysregulation of miRNAs is a frequent event in several diseases, including …
MiR-125 in normal and malignant hematopoiesis
L Shaham, V Binder, N Gefen, A Borkhardt, S Izraeli - Leukemia, 2012 - nature.com
MiR-125 is a highly conserved microRNA throughout many different species from nematode
to humans. In humans, there are three homologs (hsa-miR-125b-1, hsa-miR-125b-2 and …
to humans. In humans, there are three homologs (hsa-miR-125b-1, hsa-miR-125b-2 and …
Oncomir miR-125b regulates hematopoiesis by targeting the gene Lin28A
AA Chaudhuri, AYL So, A Mehta… - Proceedings of the …, 2012 - National Acad Sciences
MicroRNA-125b (miR-125b) is up-regulated in patients with leukemia. Overexpression of
miR-125b alone in mice causes a very aggressive, transplantable myeloid leukemia. Before …
miR-125b alone in mice causes a very aggressive, transplantable myeloid leukemia. Before …