The idea that tumour microenvironment (TME) is organised in a spatial manner will not
surprise many cancer biologists; however, systematically capturing spatial architecture of …

MALDI Imaging mass spectrometry has entered the field of tissue-based research by
providing unique advantages for analyzing tissue specimen in an unprecedented detail. A …

Characterization of tumor metabolism with spatial information contributes to our
understanding of complex cancer metabolic reprogramming, facilitating the discovery of …

Mass spectrometry is being used in many clinical research areas ranging from toxicology to
personalized medicine. Of all the mass spectrometry techniques, mass spectrometry …

MALDI mass spectrometry imaging is able to simultaneously determine the spatial
distribution of hundreds of molecules directly from tissue sections, without labeling and …

Matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) imaging mass
spectrometry (IMS) is an evolving technique in cancer diagnostics and combines the …

An essential and so far unresolved factor influencing the evolution of cancer and the clinical
management of patients is intratumour clonal and phenotypic heterogeneity. However, the …

Spatial proteomics has the potential to significantly advance our understanding of biology,
physiology and medicine. Matrix-assisted laser desorption/ionisation mass spectrometry …

Osteoarthritis (OA) is a debilitating degenerative disease affecting multiple joint tissues,
including cartilage, bone, synovium, and adipose tissues. OA presents diverse clinical …

The processes contributing to β cell dysfunction in type 2 diabetes (T2D) are uncertain,
largely because it is difficult to access β cells in their intact immediate environment. We …