Plasma high density lipoproteins (HDL) are small, dense, protein-rich particles compared
with other lipoprotein classes; roughly half of total HDL mass is accounted for by lipid …

Fibroblast growth factors (FGFs) are a family of heparin-binding growth factors. FGFs exert
their pro-angiogenic activity by interacting with various endothelial cell surface receptors …

Haploinsufficiency of GRN causes frontotemporal dementia (FTD). The GRN locus produces
progranulin (PGRN), which is cleaved to lysosomal granulin polypeptides. The function of …

Background: Clinical lipid measurements do not show the full complexity of the altered lipid
metabolism associated with diabetes mellitus or cardiovascular disease. Lipidomics enables …

For> 4 decades it has been recognized that elevated serum levels of high-density
lipoprotein cholesterol (HDL-C) are associated with reduced risk of cardiovascular disease …

Several cell surface molecules including signalling receptors are internalized by clathrin-
independent endocytosis. How this process is initiated, how cargo proteins are sorted and …

Cholesterol is a major constituent of the human brain, and the brain is the most cholesterol‐
rich organ. Numerous lipoprotein receptors and apolipoproteins are expressed in the brain …

Cutting-edge lipidomic profiling measures hundreds or even thousands of lipids in plasma
and is increasingly used to investigate mechanisms of cardiovascular disease (CVD). In this …

Malignant glioblastomas (gliomas) account for approximately one third of all diagnosed
brain tumors. Yet, a decade of research has made little progress in advancing the treatment …

Sialic acid (SA), N‐acetylated derivatives of neuraminic acid, play a central role in the
biomedical functioning of humans. The normal range of total sialic acid (TSA) level in …