Mitochondria are associated with various cellular activities critical to homeostasis,
particularly in the nervous system. The plastic architecture of the mitochondrial network and …

A determinant of axon regeneration is the intrinsic growth ability of injured neurons, which
dictates a battery of injury responses in axons and cell bodies. While some of these …

After an injury in the adult mammalian central nervous system (CNS), lesioned axons fail to
regenerate. This failure to regenerate contrasts with axons' remarkable potential to grow …

Highlights•Growth cone formation requires a precise actin and microtubule organization.•
Modulating cytoskeleton stability affects growth cone formation and axon elongation.• …

Axon regeneration is essential to restore the nervous system after axon injury. However, the
neuronal cell biology that underlies axon regeneration is incompletely understood. Here we …

Mitochondria are key cellular power plants essential for neuronal growth, survival, function,
and regeneration after injury. Given their unique morphological features, neurons face …

Mitochondria are dynamic organelles that undergo transport, fission, and fusion. The three
main functions of mitochondria are to generate ATP, buffer cytosolic calcium, and generate …

Mitochondrial transport is crucial for neuronal and axonal physiology. However, whether and
how it impacts neuronal injury responses, such as neuronal survival and axon regeneration …

Axon regeneration in the CNS is inhibited by many extrinsic and intrinsic factors. Because
these act in parallel, no single intervention has been sufficient to enable full regeneration of …

Astrocytes have emerged for playing important roles in brain tissue repair; however, the
underlying mechanisms remain poorly understood. We show that acute injury and blood …