Epigenetic regulation of mitochondrial DNA (mtDNA) is an emerging and fast-developing
field of research. Compared to regulation of nucler DNA, mechanisms of mtDNA epigenetic …

The current concept of radiobiology posits that damage to the DNA in the cell nucleus is the
primary cause for the detrimental effects of radiation. However, emerging experimental …

In the recent years, knowledge about cancer biomarkers has increased tremendously
providing great opportunities for improving the management of cancer patients by …

The purpose of this review is to give a brief background to enable the judicious use of widely
performed serum cancer markers. The markers could be product of cancerous cell or as …

There are several definitions of biomarkers. A biomarker is a characteristic that can be
objectively measured and evaluated as an indicator of a physiological as well as a …

Cytoplasmic hybrid (cybrid) cell lines can incorporate human subject mitochondria and
perpetuate its mitochondrial DNA (mtDNA)-encoded components. Since the nuclear …

Background Mitochondria provide most of the energy for brain cells by the process of
oxidative phosphorylation. Mitochondrial abnormalities and deficiencies in oxidative …

The accumulation of mitochondrial DNA (mtDNA) mutations has been proposed as an
underlying cause of the ageing process and mutations have been associated with cancer in …

The cytoplasmic hybrid (cybrid) technique allows investigators to express selected
mitochondrial DNA (mtDNA) sequences against fixed nuclear DNA (nDNA) backgrounds …

Mitochondria can perform multiple cellular functions including energy production, cell
proliferation and apoptosis. These organelles contain their own genetic material …