Biological activity of oxadiazole and thiadiazole derivatives

UA Atmaram, SM Roopan - Applied Microbiology and Biotechnology, 2022 - Springer
The 5-membered oxadiazole and thiadiazole scaffolds are the most privileged and well-
known heterocycles, being a common and essential feature of a variety of natural products …

2-Amino-1, 3, 4-thiadiazole as a potential scaffold for promising antimicrobial agents

G Serban, O Stanasel, E Serban… - Drug design, development …, 2018 - Taylor & Francis
Pathogenic microorganisms are causative agents for different types of serious and even
lethal infectious diseases. Despite advancements in medication, bacterial and fungal …

Recent advances in 1, 2, 4‐triazole scaffolds as antiviral agents

SA El‐Sebaey - ChemistrySelect, 2020 - Wiley Online Library
In recent years, severe viral infections have emerged, and antiviral chemotherapeutic agents
are not adequately effective in curing these infections, leading to serious human diseases …

Diverse biological activities of 1, 3, 4-thiadiazole scaffold

T Anthwal, S Paliwal, S Nain - Chemistry, 2022 - mdpi.com
The chemistry of 1, 3, 4-thiadiazole is one of the most interesting scaffolds for synthesizing
new drug molecules due to their numerous pharmacological activities. Several modifications …

[HTML][HTML] Mechanism-based approaches of 1, 3, 4 thiadiazole scaffolds as potent enzyme inhibitors for cytotoxicity and antiviral activity

D Kumar, H Kumar, V Kumar, A Deep, A Sharma… - Medicine in Drug …, 2023 - Elsevier
Significant progress in understanding cancer pathogenesis, it remains one of the leading
causes of death after cardiovascular diseases. Similarly viral infections have emerged from …

Synthetic compounds with 2-amino-1, 3, 4-thiadiazole moiety against viral infections

G Serban - Molecules, 2020 - mdpi.com
Viral infections have resulted in millions of victims in human history. Although great efforts
have been made to find effective medication, there are still no drugs that truly cure viral …

Synthesis and antifungal activity of novel myrtenal-based 4-methyl-1, 2, 4-triazole-thioethers

GS Lin, WG Duan, LX Yang, M Huang, FH Lei - Molecules, 2017 - mdpi.com
A series of novel myrtenal derivatives bearing 1, 2, 4-triazole moiety were designed and
synthesized by multi-step reactions in an attempt to develop potent antifungal agents. Their …

Advances in the application of 1, 2, 4-triazole-containing hybrids as anti-tuberculosis agents

Y Cao, H Lu - Future Medicinal Chemistry, 2021 - Taylor & Francis
Tuberculosis is a deadly communicable disease caused by the bacillus Mycobacterium
tuberculosis (MTB), and pulmonary tuberculosis accounts for over 80% of the total cases …

[HTML][HTML] Design, synthesis, and molecular docking studies of a conjugated thiadiazole–thiourea scaffold as antituberculosis agents

E Tatar, S Karakuş, ŞG Küçükgüzel… - Biological and …, 2016 - jstage.jst.go.jp
Design, Synthesis, and Molecular Docking Studies of a Conjugated Thiadiazole–Thiourea
Scaffold as Antituberculosis Agents Toggle navigation J-STAGE home Browse All titles All …

Synthetic transformations and medicinal significance of 1, 2, 3-thiadiazoles derivatives: An update

A Irfan, S Ullah, A Anum, N Jabeen, AF Zahoor… - Applied Sciences, 2021 - mdpi.com
The 1, 2, 3-thiadiazole moiety occupies a significant and prominent position among
privileged heterocyclic templates in the field of medicine, pharmacology and pharmaceutics …