Antipsychotic drugs are central to the treatment of schizophrenia and other psychotic
disorders but are ineffective for some patients and associated with side-effects and …

Developing reliable, predictive animal models for complex psychiatric disorders, such as
schizophrenia, is essential to increase our understanding of the neurobiological basis of the …

Since the introduction of chlorpromazine and throughout the development of the new-
generation antipsychotic drugs (APDs) beginning with clozapine, the D 2 receptor has been …

Antipsychotic drugs (APDs) are best classified as typical or atypical. The distinction is based
solely on their ability to cause extrapyramidal side effects (EPS), including tardive dyskinesia …

Although schizophrenia is an illness that has been historically characterized by the
presence of positive symptomatology, decades of research highlight the importance of …

Exposing mammals to early-life adverse events, including maternal separation or social
isolation, profoundly affects brain development and adult behaviour and may contribute to …

The main class of atypical antipsychotic drugs (APDs) in current use includes the protypical
atypical APD, clozapine, as well as aripiprazole, asenapine, iloperidone, lurasidone …

Aerobic exercise (AE) has been widely praised for its potential benefits to cognition and
overall brain and mental health. In particular, AE has a potent impact on promoting the …

The lack of efficacy for antipsychotics with respect to negative symptoms and cognitive
deficits is a significant obstacle for the treatment of schizophrenia. Developing new drugs to …

Neuropsychiatric disorders such as schizophrenia are associated with cognitive impairment,
including learning, memory and attention deficits. Antipsychotic drugs are limited in their …