Physiologically based pharmacokinetic (PBPK) modelling is a bottom-up approach to predict
pharmacokinetics in specific populations based on population-specific and medicine …

As pregnant women are constantly exposed to drugs during pregnancy, either to treat long-
term conditions or acute illnesses, drug safety is a major concern for the fetus and the …

Pregnant women are still viewed as therapeutic orphans to the extent that they are avoided
as participants in mainstream clinical trials and not considered a priority for targeted drug …

Background: Physiological changes in pregnancy may affect drug safety and efficacy,
sometimes requiring dose adjustments. Pregnancy-adjusted doses, however, are missing …

Introduction Optimizing drug therapy during pregnancy is crucial for ensuring the safety of
mothers and babiesPhysiological changes that occur during pregnancy can significantly …

Depression is common in pregnant women. However, the rate of antidepressant treatment in
pregnancy is significantly lower than in nonpregnant women. Although some …

Obstetric subjects represent a special population in pharmacology. During pregnancy and in
the postpartum period, various anatomical and physiological changes give rise to altered …

Pharmacometrics is a branch of pharmacology that uses mathematical models of biology,
pharmacology, physiology and pathophysiology to describe and quantify interactions …

Facilitating global collaborations for pregnancy and pediatric biomarker research through a
biobank database: the Collaborative Online Perinatal & Pediatric Repository project - American …

The MPRINT hub data, model, knowledge and research coordination center: bridging the
gap in maternal-pediatric therapeutics research through data integration and …