Neuromodulation by extracellular ATP and P2X receptors in the CNS
BS Khakh, RA North - Neuron, 2012 - cell.com
Extracellular adenosine 5′ triphosphate (ATP) is a widespread cell-to-cell signaling
molecule in the brain, where it activates cell surface P2X and P2Y receptors. P2X receptors …
molecule in the brain, where it activates cell surface P2X and P2Y receptors. P2X receptors …
P2X receptors as cell-surface ATP sensors in health and disease
BS Khakh, R Alan North - Nature, 2006 - nature.com
P2X receptors are membrane ion channels activated by the binding of extracellular
adenosine triphosphate (ATP). For years their functional significance was consigned to …
adenosine triphosphate (ATP). For years their functional significance was consigned to …
Signaling at purinergic P2X receptors
A Surprenant, RA North - Annual review of physiology, 2009 - annualreviews.org
P2X receptors are membrane cation channels gated by extracellular ATP. Seven P2X
receptor subunits (P2X1-7) are widely distributed in excitable and nonexcitable cells of …
receptor subunits (P2X1-7) are widely distributed in excitable and nonexcitable cells of …
P2X receptors as drug targets
RA North, MF Jarvis - Molecular pharmacology, 2013 - ASPET
The study of P2X receptors has long been handicapped by a poverty of small-molecule tools
that serve as selective agonists and antagonists. There has been progress, particularly in …
that serve as selective agonists and antagonists. There has been progress, particularly in …
Molecular and functional properties of P2X receptors—recent progress and persisting challenges
K Kaczmarek-Hájek, É Lörinczi, R Hausmann… - Purinergic …, 2012 - Springer
Abstract ATP-gated P2X receptors are trimeric ion channels that assemble as homo-or
heteromers from seven cloned subunits. Transcripts and/or proteins of P2X subunits have …
heteromers from seven cloned subunits. Transcripts and/or proteins of P2X subunits have …
A functional P2X7 splice variant with an alternative transmembrane domain 1 escapes gene inactivation in P2X7 knock-out mice
A Nicke, YH Kuan, M Masin, J Rettinger… - Journal of Biological …, 2009 - ASBMB
The ATP-activated P2X7 receptor channel is involved in immune function and inflammatory
pain and represents an important drug target. Here we describe a new P2X7 splice variant …
pain and represents an important drug target. Here we describe a new P2X7 splice variant …
Expression, assembly and function of novel C‐terminal truncated variants of the mouse P2X7 receptor: re‐evaluation of P2X7 knockouts
M Masin, C Young, KN Lim, SJ Barnes… - British journal of …, 2012 - Wiley Online Library
BACKGROUND AND PURPOSE Splice variants of P2X7 receptor transcripts contribute to
the diversity of receptor‐mediated responses. Here, we investigated expression and function …
the diversity of receptor‐mediated responses. Here, we investigated expression and function …
Molecular properties of P2X receptors
JA Roberts, C Vial, HR Digby, KC Agboh, H Wen… - Pflügers Archiv, 2006 - Springer
P2X receptors for adenosine tri-phosphate (ATP) are a distinct family of ligand-gated cation
channels with two transmembrane domains, intracellular amino and carboxy termini and a …
channels with two transmembrane domains, intracellular amino and carboxy termini and a …
The FE65 proteins and Alzheimer's disease
DM McLoughlin, CCJ Miller - Journal of neuroscience research, 2008 - Wiley Online Library
Abstract The FE65s (FE65, FE65L1, and FE65L2) are a family of multidomain adaptor
proteins that form multiprotein complexes with a range of functions. FE65 is brain‐enriched …
proteins that form multiprotein complexes with a range of functions. FE65 is brain‐enriched …
β-Amyloid precursor protein metabolism: focus on the functions and degradation of its intracellular domain
Alzheimer's disease (AD) is a neurodegenerative disorder that represents the most common
type of dementia in the elderly. One of the hallmarks of this disease is a progressive …
type of dementia in the elderly. One of the hallmarks of this disease is a progressive …