The binding affinity determination of protein–ligand complexes is a cornerstone of drug
design. State-of-the-art techniques are limited by lengthy and expensive processes. Building …

Nuclear magnetic resonance (NMR) is recognized as the gold standard method in fragment‐
based drug design for screening, hit validation, and affinity determination. However, its …

Laplace NMR is a powerful tool for studying molecular dynamics and spin interactions,
providing diffusion and relaxation information that complements Fourier NMR used for …

Hyperpolarization derived from water protons enhances the NMR signal of 15N nuclei in a
small molecule, enabling the sensitive detection of a protein–ligand interaction. The water …

Dissolution dynamic nuclear polarization (d-DNP) has enabled applications such as the real-
time monitoring of chemical reactions. Such applications are mainly for 13C and 15N spins …

It is shown that proton spins highly polarized by dynamic nuclear polarization (DNP) retain
substantial polarization upon the rapid transfer of frozen bullets from a polarizer to an NMR …

Ultrafast nuclear magnetic resonance (NMR) uses spatial encoding to record an entire two-
dimensional data set in just a single scan. The approach can be applied to either Fourier …

Proteiini-ligandivuorovaikutuksiin vaikuttaa kolme tekijää: 1. kuinka paljon pro-teiineja ja
ligandeja liuoksessa on vapaana, 2. paljonko komplekseja liuoksessa on, sekä 3. kuinka …