Progress and Challenges in the Field of Snakebite Envenoming Therapeutics

JM Gutiérrez, N R. Casewell… - Annual Review of …, 2024 - annualreviews.org
Snakebite envenoming kills and maims hundreds of thousands of people every year,
especially in the rural settings of tropical regions. Envenomings are still treated with animal …

Venoms of Micrurus coral snakes: Evolutionary trends in compositional patterns emerging from proteomic analyses

B Lomonte, P Rey-Suárez, J Fernández, M Sasa, D Pla… - Toxicon, 2016 - Elsevier
The application of proteomic tools to the study of snake venoms has led to an impressive
growth in the knowledge about their composition (venomics), immunogenicity …

[PDF][PDF] Antivenomics and its role in enhancing cobra envenomation treatments: A review of current practices and future prospects

I Karunarathna, K De Alvis, P Gunasena… - 2024 - researchgate.net
The King Cobra (Ophiophagus hannah) holds cultural significance and is one of the most
medically important venomous snakes worldwide. Envenomation by King Cobras often …

[PDF][PDF] Innovative approaches to neutralizing cobra venom: Advances in antivenomics and recombinant antivenoms

I Karunarathna, K De Alvis, P Gunasena… - 2024 - researchgate.net
The King Cobra (Ophiophagus hannah) holds cultural significance and is one of the most
medically important venomous snakes worldwide. Envenomation by King Cobras often …

Current technology for the industrial manufacture of snake antivenoms

G León, M Vargas, Á Segura, M Herrera, M Villalta… - Toxicon, 2018 - Elsevier
Snake antivenoms are formulations of animal immunoglobulins used in the treatment of
snakebite envenomation. The general scheme for producing snake antivenoms has …

Snake venomics: fundamentals, recent updates, and a look to the next decade

CH Tan - Toxins, 2022 - mdpi.com
Venomic research, powered by techniques adapted from proteomics, transcriptomics, and
genomics, seeks to unravel the diversity and complexity of venom through which knowledge …

[HTML][HTML] Immunoglobulin fragment F (ab') 2 against RBD potently neutralizes SARS-CoV-2 in vitro

X Pan, P Zhou, T Fan, Y Wu, J Zhang, X Shi, W Shang… - Antiviral research, 2020 - Elsevier
COVID-19, which is caused by the emerging human coronavirus SARS-CoV-2, has become
a global pandemic that poses a serious threat to human health. To date, no vaccines or …

An analysis of preclinical efficacy testing of antivenoms for sub-Saharan Africa: Inadequate independent scrutiny and poor-quality reporting are barriers to improving …

S Ainsworth, SK Menzies, NR Casewell… - PLOS Neglected …, 2020 - journals.plos.org
Background The World Health Organization's strategy to halve snakebite mortality and
morbidity by 2030 includes an emphasis on a risk-benefit process assessing the preclinical …

Polyvalent snake antivenoms: production strategy and their therapeutic benefits

K Ratanabanangkoon - Toxins, 2023 - mdpi.com
Snake envenomation remains an important yet neglected medical problem in many
countries, with around five million people affected, and over a hundred thousand deaths …

Venomics of Bungarus caeruleus (Indian krait): Comparable venom profiles, variable immunoreactivities among specimens from Sri Lanka, India and Pakistan

AMF Oh, CH Tan, GC Ariaranee, N Quraishi… - Journal of proteomics, 2017 - Elsevier
Abstract The Indian krait (Bungarus caeruleus) is one of the “Big Four” venomous snakes
widely distributed in South Asia. The present venomic study reveals that its venom (Sri …