The metabolism and significance of homocysteine in nutrition and health

A Kumar, HA Palfrey, R Pathak, PJ Kadowitz… - Nutrition & …, 2017 - Springer
An association between arteriosclerosis and homocysteine (Hcy) was first demonstrated in
1969. Hcy is a sulfur containing amino acid derived from the essential amino acid …

Salidroside suppressing LPS‐induced myocardial injury by inhibiting ROS‐mediated PI3K/Akt/mTOR pathway in vitro and in vivo

L Chen, P Liu, X Feng, C Ma - Journal of Cellular and …, 2017 - Wiley Online Library
The purpose of the present study was to investigate the effect of salidroside (Sal) on
myocardial injury in lipopolysaccharide (LPS)‐induced endotoxemic in vitro and in vivo. SD …

Nebivolol ameliorates cisplatin‐induced nephrotoxicity in rats

MA Morsy, GH Heeba - Basic & clinical pharmacology & …, 2016 - Wiley Online Library
Abstract Treatment with cisplatin is associated with dose‐limiting side effects, mainly
nephrotoxicity. On the other hand, nebivolol, a β1‐adrenoceptor antagonist, exhibits …

Modulation of eNOS/iNOS by nebivolol protects against cyclosporine A-mediated nephrotoxicity through targeting inflammatory and apoptotic pathways

AAK El-Sheikh, MA Morsy, RG Abdel-Latif - Environmental toxicology and …, 2019 - Elsevier
The aim of this study was to investigate effect of nitric oxide (NO) modulation on possible
nephroprotective mechanisms of nebivolol (NEB) in cyclosporine A (CsA)-induced …

Salidroside attenuates LPS-induced acute lung injury in rats

L Jingyan, G Yujuan, Y Yiming, Z Lingpeng, Y Tianhua… - Inflammation, 2017 - Springer
The purpose of the present study was to investigate the effects of salidroside (Sal) on lung
injury in lipopolysaccharide (LPS)-induced endotoxemic in vitro and in vivo. SD rats were …

Vitamin B complex mitigates cardiac dysfunction in high‐methionine diet‐induced hyperhomocysteinemia

J Jeremic, T Nikolic Turnic, V Zivkovic… - Clinical and …, 2018 - Wiley Online Library
This research is designed to test the hypothesis that elevated homocysteine (Hcy) levels in
vivo, caused by a deficit in vitamin B complex, promote changes in cardiac function and …

Protective effects of nebivolol on acetic acid-induced ulcerative colitis in rats

DA Aly Labib, OG Shaker, LO Elfarouk - Kasr Al Ainy Medical …, 2016 - journals.ekb.eg
BackgroundUlcerative colitis (UC) is a chronic inflammatory disease of large intestine.
Overproduction of free radicals, lowered antioxidant capacity and abnormal apoptosis are …

Different effects of selective β1‐adrenoceptor antagonists, nebivolol or atenolol in acetaminophen‐induced hepatotoxicity of rats

RR Rofaeil, MY Kamel… - Fundamental & Clinical …, 2017 - Wiley Online Library
Acetaminophen (APAP) overdose is a common cause of acute liver failure, and beta‐
blockers are commonly used drugs in clinical practice. This study aimed to evaluate the …

[HTML][HTML] Vascular protection of TPE-CA on hyperhomocysteinemia-induced vascular endothelial dysfunction through AA metabolism modulated CYPs pathway

H Li, Z Liu, L Liu, W Li, Z Cao, Z Song… - … Journal of Biological …, 2019 - ncbi.nlm.nih.gov
A high concentration of homocysteine (Hcy) in plasma induces vascular endothelial
dysfunction, and it may ultimately accelerate the development of cardiovascular diseases …

Metoprolol and nebivolol prevent the decline of the redox status of low-molecular-weight aminothiols in blood plasma of rats during acute cerebral ischemia

AV Ivanov, VV Alexandrin, AA Paltsyn… - Journal of …, 2018 - journals.lww.com
Cerebral ischemia has previously been shown to cause a systemic decrease in levels of the
reduced forms of low-molecular-weight aminothiols [cysteine (Cys), homocysteine (Hcy) …