The role of human milk nutrients in preventing necrotizing enterocolitis

AS Sami, LC Frazer, CM Miller, DK Singh… - Frontiers in …, 2023 - frontiersin.org
Necrotizing enterocolitis (NEC) is an intestinal disease that primarily impacts preterm infants.
The pathophysiology of NEC involves a complex interplay of factors that result in a …

The Impact of Stress, Microbial Dysbiosis, and Inflammation on Necrotizing Enterocolitis

V Yeramilli, R Cheddadi, H Benjamin, C Martin - Microorganisms, 2023 - mdpi.com
Necrotizing enterocolitis (NEC) is the leading cause of intestinal morbidity and mortality in
neonates. A large body of work exists; however, the pathogenesis of NEC remains poorly …

Identification of omega-3 oxylipins in human milk-derived extracellular vesicles with pro-resolutive actions in gastrointestinal inflammation

M Gómez-Ferrer, E Amaro-Prellezo… - Frontiers in …, 2023 - frontiersin.org
Introduction Premature infants (PIs) are at risk of suffering necrotizing enterocolitis (NEC),
and infants consuming human milk (HM) show a lower incidence than infants receiving …

An anti-eCIRP strategy for necrotizing enterocolitis

CP Nofi, JM Prince, MR Brewer, M Aziz, P Wang - Molecular Medicine, 2024 - Springer
Background Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease
characterized by intestinal inflammation and injury, with high mortality risk. Extracellular cold …

Anti-Inflammatory and anti-allergic properties of colostrum from mothers of full-term and preterm babies: The importance of maternal lactation in the first days

F Garofoli, E Civardi, C Pisoni, M Angelini… - Nutrients, 2023 - mdpi.com
Our narrative review focuses on colostrum components, particularly those that influence the
neonatal immune system of newborns. Colostrum is secreted in small volumes by the …

Multi-strain probiotic administration decreases necrotizing enterocolitis severity and alters the epigenetic profile in mice

DH Klerk, H Moore, DJ Scheese, C Tragesser… - Pediatric …, 2024 - nature.com
Background Probiotic administration may decrease the incidence of necrotizing enterocolitis
(NEC) through mechanisms that are largely unknown. We investigated the effects of …

[HTML][HTML] Apnea of Prematurity and Oxidative Stress: Potential Implications

L Thompson, JW Werthammer, D Gozal - Antioxidants, 2024 - mdpi.com
Apnea of prematurity (AOP) occurs in 85% of neonates≤ 34 weeks of gestational age. AOP
is frequently associated with intermittent hypoxia (IH). This narrative review reports on the …

Chromatin as alarmins in necrotizing enterocolitis

CP Nofi, JM Prince, P Wang, M Aziz - Frontiers in Immunology, 2024 - frontiersin.org
Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease primarily affecting
premature neonates, marked by poorly understood pro-inflammatory signaling cascades …

Modulation of intestinal TLR4 expression in infants with neonatal opioid withdrawal syndrome

RC Barnett, AN Lewis, Q Gong, DL Preston… - Journal of …, 2024 - nature.com
Abstract Objective Neonatal Opioid Withdrawal Syndrome (NOWS) has been associated
with the development of necrotizing enterocolitis (NEC) in term and late-preterm neonates …

DNA methylation in necrotizing enterocolitis

LC Frazer, Y Yamaguchi, DK Singh… - Expert Reviews in …, 2024 - cambridge.org
Funding Sources: LCF is supported by a Thrasher Research Fund Early Career Award, UNC
School of Medicine Physician Scientist Training Program Faculty Award, UNC Children's …