The immune system is highly time-of-day dependent. Pioneering studies in the 1960s were
the first to identify immune responses to be under a circadian control. Only in the last …

Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral
processes. The central circadian clock exerts control over myriad aspects of mammalian …

Environmental light cycles entrain circadian feeding behaviors in animals that produce
rhythms in exposure to foodborne bacteria. Here, we show that the intestinal microbiota …

Circadian rhythms are a ubiquitous feature of virtually all living organisms, regulating a wide
diversity of physiological systems. It has long been established that the circadian clockwork …

The circadian clock, a highly specialized, hierarchical network of biological pacemakers,
directs and maintains proper rhythms in endocrine and metabolic pathways required for …

Animals receive environmental stimuli from neural signals in order to produce hormones that
control immune responses. Glucocorticoids (GCs) are a group of steroid hormones …

Recent discoveries demonstrate a critical role for circadian rhythms and sleep in immune
system homeostasis. Both innate and adaptive immune responses—ranging from leukocyte …

Certain members of the gut microbiota exhibit diurnal variations in relative abundance and
function to serve as non-canonical drivers of host circadian rhythms and metabolism. Also …

This article reviews the current evidence associating gut microbiota with factors that impact
host circadian-metabolic axis, such as light/dark cycles, sleep/wake cycles, diet, and eating …

Productive T cell responses to infection and cancer rely on coordinated metabolic
reprogramming and epigenetic remodeling among the immune cells. In particular, T cell …