Novel human iPSC models of neuroinflammation in neurodegenerative disease and regenerative medicine
The importance of neuroinflammation in neurodegenerative diseases is becoming
increasingly evident, and, in parallel, human induced pluripotent stem cell (hiPSC) models …
increasingly evident, and, in parallel, human induced pluripotent stem cell (hiPSC) models …
Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis
RB Ionescu, AM Nicaise, JA Reisz, EC Williams… - Cell Stem Cell, 2024 - cell.com
Senescent neural progenitor cells have been identified in brain lesions of people with
progressive multiple sclerosis (PMS). However, their role in disease pathobiology and …
progressive multiple sclerosis (PMS). However, their role in disease pathobiology and …
Neurodegeneration and demyelination in multiple sclerosis
Progressive multiple sclerosis (PMS) is an immune-initiated neurodegenerative condition
that lacks effective therapies. Although peripheral immune infiltration is a hallmark of …
that lacks effective therapies. Although peripheral immune infiltration is a hallmark of …
All roads lead to cholesterol: Modulating lipid biosynthesis in multiple sclerosis patient-derived models
Studies from Ionescu et al. 1 and Clayton et al. 2 using multiple sclerosis (MS) patient-
derived cell models underscore cholesterol metabolism's role in inflammatory and …
derived cell models underscore cholesterol metabolism's role in inflammatory and …
Effects of microgravity on human iPSC-derived neural organoids on the International Space Station
Research conducted on the International Space Station (ISS) in low-Earth orbit (LEO) has
shown the effects of microgravity on multiple organs. To investigate the effects of …
shown the effects of microgravity on multiple organs. To investigate the effects of …
Integrative single-cell analysis of neural stem/progenitor cells reveals epigenetically dysregulated interferon response in progressive multiple sclerosis
Progressive multiple sclerosis (PMS) is characterized by a primary smouldering pathological
disease process associated with a superimposed inflammatory activity. Cellular and …
disease process associated with a superimposed inflammatory activity. Cellular and …
[HTML][HTML] A glia-enriched stem cell 3D model of the human brain mimics the glial-immune neurodegenerative phenotypes of multiple sclerosis
F Fagiani, E Pedrini, S Taverna, E Brambilla… - Cell Reports …, 2024 - cell.com
The role of central nervous system (CNS) glia in sustaining self-autonomous inflammation
and driving clinical progression in multiple sclerosis (MS) is gaining scientific interest. We …
and driving clinical progression in multiple sclerosis (MS) is gaining scientific interest. We …