Beyond E-cadherin: roles of other cadherin superfamily members in cancer
F Van Roy - Nature Reviews Cancer, 2014 - nature.com
Abstract Loss of cadherin 1 (CDH1; also known as epithelial cadherin (E-cadherin)) is used
for the diagnosis and prognosis of epithelial cancers. However, it should not be ignored that …
for the diagnosis and prognosis of epithelial cancers. However, it should not be ignored that …
EMT‐and MET‐related processes in nonepithelial tumors: importance for disease progression, prognosis, and therapeutic opportunities
The epithelial‐to mesenchymal (EMT) process is increasingly recognized for playing a key
role in the progression, dissemination, and therapy resistance of epithelial tumors …
role in the progression, dissemination, and therapy resistance of epithelial tumors …
A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis
Osteosarcomas are sarcomas of the bone, derived from osteoblasts or their precursors, with
a high propensity to metastasize. Osteosarcoma is associated with massive genomic …
a high propensity to metastasize. Osteosarcoma is associated with massive genomic …
Unraveling the roles of miRNAs in regulating epithelial-to-mesenchymal transition (EMT) in osteosarcoma
Osteosarcoma is one of the most prevalent primary bone tumors with a high metastatic and
recurrence rate with poor prognosis. MiRNAs are short and non-coding RNAs that could …
recurrence rate with poor prognosis. MiRNAs are short and non-coding RNAs that could …
Cyclin D1, Id1 and EMT in breast cancer
Background Cyclin D1 is a well-characterised cell cycle regulator with established
oncogenic capabilities. Despite these properties, studies report contrasting links to tumour …
oncogenic capabilities. Despite these properties, studies report contrasting links to tumour …
The human cadherin 11 is a pro-apoptotic tumor suppressor modulating cell stemness through Wnt/β-catenin signaling and silenced in common carcinomas
Genetic alterations of 16q21-q22, the locus of a 6-cadherin cluster, are frequently involved in
multiple tumors, suggesting the presence of critical tumor suppressor genes (TSGs). Using 1 …
multiple tumors, suggesting the presence of critical tumor suppressor genes (TSGs). Using 1 …
The tumor microenvironment of pediatric sarcoma: mesenchymal mechanisms regulating cell migration and metastasis
Abstract Purpose of Review This review presents a selection of regulatory molecules of
tumor microenvironmental properties and metastasis. Signaling pathways controlling …
tumor microenvironmental properties and metastasis. Signaling pathways controlling …
[HTML][HTML] A 3D-printed scaffold-based osteosarcoma model allows to investigate tumor phenotypes and pathogenesis in an in vitro bone-mimicking niche
ML Wang, NY Xu, RZ Tang, XQ Liu - Materials Today Bio, 2022 - Elsevier
The pronounced influence of extracellular matrix (ECM) on bone tumor progression and
metastasis have gained increased attention, which is difficult to reflect in current in vitro …
metastasis have gained increased attention, which is difficult to reflect in current in vitro …
Epigenetic disruption of cadherin‐11 in human cancer metastasis
FJ Carmona, A Villanueva, A Vidal… - The Journal of …, 2012 - Wiley Online Library
Little is known about the molecular events occurring in the metastases of human tumours.
Epigenetic alterations are dynamic lesions that change over the natural course of the …
Epigenetic alterations are dynamic lesions that change over the natural course of the …
[HTML][HTML] Mesenchymal to epithelial transition in sarcomas
J Yang, X Du, G Wang, Y Sun, K Chen, X Zhu… - European journal of …, 2014 - Elsevier
Mesenchymal to epithelial transition (MET) in carcinomas has been proposed to promote the
growth of epithelial tumour cells at distant sites during metastasis. MET has also been …
growth of epithelial tumour cells at distant sites during metastasis. MET has also been …