Three ATP-binding cassette (ABC)-superfamily multidrug efflux pumps are known to be
responsible for chemoresistance; P-glycoprotein (ABCB1), MRP1 (ABCC1) and ABCG2 …

Over 1 million new cases of all types of cancer are diagnosed each year in the United States
alone, and 559 650 cancer-related deaths were expected to occur in 2007. 1 …

Members of the superfamily of ATP-binding cassette (ABC) transporters mediate the
movement of a variety of substrates including simple ions, complex lipids and xenobiotics. At …

P-glycoprotein (P-gp) the multidrug transporter is a well-characterised member of the super-
family of ATP-binding cassette (ABC) transporters, and mediates the clearance of xenotoxins …

P-glycoprotein (ABCB1), a member of the ABC superfamily, functions as an ATP-driven
multidrug efflux pump. The catalytic cycle of ABC proteins is believed to involve formation of …

P-glycoprotein (Pgp; ABCB1), a member of the ATP-binding cassette (ABC) superfamily,
exports structurally diverse hydrophobic compounds from the cell, driven by ATP hydrolysis …

P-glycoprotein (P-gp) is a critical membrane transporter in the blood brain barrier (BBB) and
is implicated in Alzheimer's disease (AD). However, previous studies on the ability of P-gp to …

Multidrug transporters are involved in mediating the failure of chemotherapy in treating
several serious diseases. The archetypal multidrug transporter P-glycoprotein (P-gp) confers …

P-gp (P-glycoprotein; ABCB1) protects us by transporting a broad range of structurally
unrelated compounds out of the cell. Identifying the regions of P-gp that make up the drug …

P-glycoprotein (Pgp), a member of the ATP-binding cassette transporter family, functions as
an ATP hydrolysis-driven efflux pump to rid the cell of toxic organic compounds, including a …