Osteochondral grafting has demonstrated positive outcomes for treating articular cartilage
defects by replacing the damaged region with a cylindrical graft consisting of bone with a …

Tissue-level properties of bone play an important role when characterising apparent-level
bone biomechanical behaviour and yet little is known about its effect at this hierarchical …

Finite element modelling of the spinal unit is a promising preclinical tool to assess the
biomechanical outcome of emerging interventions. Currently, most models are calibrated …

Degenerative disc disease (DDD) is a common condition in elderly population that can be
painful and can significantly affect individual's quality of life. Diagnosis of DDD allows …

Vertebroplasty has been widely used for the treatment of osteoporotic compression fractures
but the efficacy of the technique has been questioned by the outcomes of randomized …

In computational modelling of musculoskeletal applications, one of the critical aspects is
ensuring that a model can capture intrinsic population variability and not only representative …

There is a strong demand for mechanically and morphologically accurate models of the
human musculoskeletal system, particularly of the spine. Such models would have multiple …

Osteoarthritis is a degenerative disease of the joint leading to pain and disability. The knee
is the most common site for osteoarthritis. Bone marrow lesions (BMLs) have been …

Over 25% of the population are expected to suffer a vertebral fracture over the course of their
lifetime (Palastanga and Soames, 2011). This can lead to severe pain and a dramatically …

Bone is a living composite material consisting of inorganic minerals, organic proteins, and
water, which approximately account for 60%, 30% and 10% of bone mass, respec-tively. In …