Cellular senescence in asthma: from pathogenesis to therapeutic challenges

R Wan, P Srikaram, V Guntupalli, C Hu, Q Chen… - …, 2023 - thelancet.com
Asthma is a heterogeneous chronic respiratory disease that impacts nearly 10% of the
population worldwide. While cellular senescence is a normal physiological process, the …

Effects of tezepelumab on quality of life of patients with moderate-to-severe, uncontrolled asthma: systematic review and meta-analysis

GCL Chagas, D Xavier, L Gomes, J Ferri-Guerra… - Current Allergy and …, 2023 - Springer
Abstract Purpose of Review To assess the effects of tezepelumab on quality of life (QoL) in
patients with moderate-to-severe, uncontrolled asthma. Recent Findings Tezepelumab …

Effects of biological therapies on patients with Type-2 high asthma and comorbid obesity

D Garg, LG Que, JL Ingram - Frontiers in Pharmacology, 2024 - frontiersin.org
Over 20 million adults and 6 million children in the United States (US) have asthma, a
chronic respiratory disease characterized by airway inflammation, bronchoconstriction, and …

Current and Novel Biologic therapies for patients with Asthma and Nasal Polyps

HK Mandl, JE Miller, DM Beswick - Otolaryngologic Clinics of …, 2023 - oto.theclinics.com
Current and Novel Biologic Therapies for Patients with Asthma and Nasal Polyps -
Otolaryngologic Clinics of North America Skip to Main Content Skip to Main Menu …

Thymic Stromal Lymphopoietin (TSLP), Its Isoforms and the Interplay with the Epithelium in Allergy and Asthma

S Smolinska, D Antolín-Amérigo, FD Popescu… - International Journal of …, 2023 - mdpi.com
Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine that has emerged as a critical
player in the development and progression of allergy and asthma. It is primarily produced by …

[HTML][HTML] Brazilian guideline for the use of immunobiologicals in chronic rhinosinusitis with nasal polyps‒2024 update

WT Anselmo-Lima, FR Romano, E Tamashiro… - Brazilian Journal of …, 2024 - Elsevier
Introduction Biologics targeting type 2 inflammation have revolutionized the way we treat
patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP). Particularly in severe …

Immunogenicity of biologics used in the treatment of asthma

OAM Neunie, W Rabbani, D Baker… - Human …, 2024 - content.iospress.com
PURPOSE OF THE REVIEW: Asthma is a major global disease affecting adults and children,
which can lead to hospitalization and death due to breathing difficulties. Although targeted …

成人重度哮喘的免疫学特征和生物靶向治疗现状及展望

孙傲, 王镜銮, 刘文娟, 任敦强… - 中国临床药理学与治疗 …, 2024 - manu41.magtech.com.cn
重度哮喘是哮喘患者致死和致残的主要因素, 可造成巨大的社会和经济压力. 近年来,
随着对哮喘病理机制的深入了解, 生物靶向治疗逐渐成为重度哮喘治疗的新选择 …

Clinical Trials and Outcomes in Anti-inflammatory Therapies

S Shukla, V Kumar, S Singh, A Dwivedi… - … Resolution and Chronic …, 2024 - Springer
Inflammatory diseases represent a diverse group of disorders stemming from an overactive
immune response, affecting various organs and tissues and manifesting a spectrum of …

Biologic Drugs for Severe Asthma

JR Randall, R Leigh, ET Crumley… - … Journal of Health …, 2024 - canjhealthtechnol.ca
Background Asthma is a spectrum of chronic conditions that exhibit airway inflammation and
hyperreactivity. 1 Severe asthma affects approximately 5% to 10% of individuals living with …