The Hedgehog signalling pathway has crucial roles in embryonic tissue patterning,
postembryonic tissue regeneration, and cancer, yet aspects of Hedgehog signal …

The Hedgehog (HH) signaling pathway was discovered originally as a key pathway in
embryonic patterning and development. Since its discovery, it has become increasingly …

Ferroptosis is a form of cell death that has received considerable attention not only as a
means to eradicate defined tumour entities but also because it provides unforeseen insights …

Cholesterol is necessary for the function of many G-protein coupled receptors (GPCRs). We
find that cholesterol is not just necessary but also sufficient to activate signaling by the …

Cilia, organelles that move to execute functions like fertilization and signal to execute
functions like photoreception and embryonic patterning, are composed of a core of nine-fold …

Primary cilia are required for Smoothened to transduce vertebrate Hedgehog signals, but
how Smoothened accumulates in cilia and is activated is incompletely understood. Here, we …

Hedgehog signaling specifies tissue patterning and renewal, and pathway components are
commonly mutated in certain malignancies. Although central to ensuring appropriate …

Hedgehog signals are transduced through Patched receptors to the Smoothened (SMO)-
SUFU-GLI and SMO-Gi-RhoA signaling cascades. MTOR-S6K1 and MEK-ERK signals are …

Previously we proposed that transmission of the hedgehog signal across the plasma
membrane by Smoothened is triggered by its interaction with cholesterol (Luchetti et al …

Every cell in vertebrates possesses the machinery to synthesise cholesterol and to
metabolise it. The major route of cholesterol metabolism is conversion to bile acids. Bile …