T cells have the ability to eliminate infected and cancer cells and play an essential role in
cancer immunotherapy. T cell activation is elicited by the binding of the T cell receptor (TCR) …

CD8 T cells provide immunity to virus infection through recognition of epitopes presented by
peptide major histocompatibility complexes (pMHCs). To establish a concise panel of widely …

The ability to predict binding between peptides presented by the Major Histocompatibility
Complex (MHC) class I molecules and T-cell receptors (TCR) is of great interest in areas of …

Predicting the interaction between Major Histocompatibility Complex (MHC) class I-
presented peptides and T-cell receptors (TCR) holds significant implications for vaccine …

Here, we present the findings from IMMREP23, the second benchmark competition focused
on predicting the specificity of TCR-pMHC interactions. The interaction of T cell receptors …

Results We propose TSpred, a new deep learning approach for the pan-specific prediction
of TCR binding specificity based on paired chain TCR data. We develop a robust model that …

Background Kidney transplant recipients receive maintenance immunosuppressive therapy
to avoid allograft rejection resulting in increased risk of infections and infection-related …

T cells targeting epitopes in infectious diseases or cancer play a central role in spontaneous
and therapy-induced immune responses. T-cell epitope recognition is mediated by the …

Prediction of T-cell receptor (TCR)-epitope interactions is important for many applications
such as cancer immunotherapy. However, due to the scarcity of available data, it is known to …