Abstract The 1, 2, 3-triazole ring is a major pharmacophore system among nitrogen-
containing heterocycles. These five-membered heterocyclic motifs with three nitrogen …

The overuse and inappropriate use of antibiotics to treat bacterial infections has led to the
development of multiple drug resistant strains. Biofilm is a complex microorganism …

The survival selection pressure caused by antibiotic-mediated bactericidal and bacteriostatic
activity is one of the important inducements for bacteria to develop drug resistance. Bacteria …

Nowadays, due to spreading antibiotic resistance among clinically relevant pathogens, the
requirement of novel therapeutic approaches is felt more than ever. One of the alternative …

Antibiotic resistance is one of the most important challenges of the 21st century. However,
the growing understanding of bacterial pathogenesis and cell-to-cell communication has …

The privileged structure binds to multiple receptors with high affinity, which is helpful to the
development of new bioactive compounds. Indole is classified as a privileged structure …

The prevalence of multidrug resistance (MDR) and stagnant drug-development pipelines
have led to the rapid rise of hard-to-treat antibiotic-resistant bacterial infections. These …

The aryl hydrocarbon receptor (AhR) protein senses microbial-secreted metabolites to
trigger the host's innate immune system. The Pseudomonas quinolone signal (PQS) and …

Bacterial pathogenesis involves complex mechanisms contributing to virulence and
persistence of infections. Understanding the multifactorial nature of bacterial infections is …

Bacteria regulate their phenotype, growth and population via a signalling pathway known as
quorum sensing. In this process, bacteria produce signalling molecules (autoinducers) to …