Dentate gyrus circuits for encoding, retrieval and discrimination of episodic memories

T Hainmueller, M Bartos - Nature Reviews Neuroscience, 2020 - nature.com
The dentate gyrus (DG) has a key role in hippocampal memory formation. Intriguingly, DG
lesions impair many, but not all, hippocampus-dependent mnemonic functions, indicating …

Contributions of adult neurogenesis to dentate gyrus network activity and computations

SN Tuncdemir, CO Lacefield, R Hen - Behavioural Brain Research, 2019 - Elsevier
Anatomical observations, theoretical work and lesion experiments have led to the idea that
an important function of the dentate gyrus of the mammalian hippocampus is pattern …

Preexisting hippocampal network dynamics constrain optogenetically induced place fields

S McKenzie, R Huszár, DF English, K Kim… - Neuron, 2021 - cell.com
Memory models often emphasize the need to encode novel patterns of neural activity
imposed by sensory drive. Prior learning and innate architecture likely restrict neural …

[HTML][HTML] Engram reactivation mimics cellular signatures of fear

RL Suthard, RA Senne, MD Buzharsky, AH Diep… - Cell Reports, 2024 - cell.com
Engrams, or the physical substrate of memory, recruit heterogeneous cell types. Targeted
reactivation of neurons processing discrete memories drives the behavioral expression of …

Theta-phase-specific modulation of dentate gyrus memory neurons

B Rahsepar, JF Norman, J Noueihed, B Lahner… - Elife, 2023 - elifesciences.org
The theta rhythm, a quasi-periodic 4–10 Hz oscillation, is observed during memory
processing in the hippocampus, with different phases of theta hypothesized to separate …

Unique potential of immature adult-born neurons for the remodeling of CA3 spatial maps

M Mugnaini, MF Trinchero, AF Schinder, VC Piatti… - Cell reports, 2023 - cell.com
Mammalian hippocampal circuits undergo extensive remodeling through adult
neurogenesis. While this process has been widely studied, the specific contribution of adult …

Structure, biophysics, and circuit function of a “giant” cortical presynaptic terminal

D Vandael, P Jonas - Science, 2024 - science.org
The hippocampal mossy fiber synapse, formed between axons of dentate gyrus granule
cells and dendrites of CA3 pyramidal neurons, is a key synapse in the trisynaptic circuitry of …

Modelling unitary fields and the single‐neuron contribution to local field potentials in the hippocampus

M Teleńczuk, B Teleńczuk… - The Journal of …, 2020 - Wiley Online Library
Key points We simulate the unitary local field potential (uLFP) generated in the
hippocampus CA3, using morphologically detailed models. The model suggests that …

Remembering rewarding futures: A simulation‐selection model of the hippocampus

MW Jung, H Lee, Y Jeong, JW Lee, I Lee - Hippocampus, 2018 - Wiley Online Library
Despite tremendous progress, the neural circuit dynamics underlying hippocampal
mnemonic processing remain poorly understood. We propose a new model for hippocampal …

Theta phase specific modulation of hippocampal memory neurons

B Rahsepar, J Noueihed, JF Norman, B Lahner… - Biorxiv, 2022 - biorxiv.org
I. Abstract The theta rhythm, a quasi-periodic 4-10 Hz oscillation, is observed during memory
processing in the hippocampus, with different phases of theta hypothesized to separate …