Radical S-adenosylmethionine (SAM) enzymes utilize a [4Fe-4S] 1+ cluster and S-(5′-
adenosyl)-L-methionine,(SAM), to generate a highly reactive radical and catalyze what is …

Class C radical SAM methyltransferases catalyze a diverse array of difficult chemical
transformations in the biosynthesis of a range of compounds of biomedical importance …

ChuW, ChuX, and ChuY are contiguous genes downstream from a single promoter that are
expressed in the enteric pathogen Escherichia coli O157: H7 when iron is limiting. These …

Edwardsiella piscicida is a severe fish pathogen. Haem utilization systems play an important
role in bacterial adversity adaptation and pathogenicity. In this study, a speculative haem …

Heme catabolism is an important biochemical process that many bacterial pathogens utilize
to acquire iron. However, tetrapyrrole catabolites can be reactive and often require further …

Background The rapid emergence of multiple drug-resistant (MDR) bacterial pathogens and
the lack of a novel antibiotic pipeline pose a serious threat to global healthcare. The limited …

Anaerobilin synthase catalyzes the decyclization of the heme protoporphyrin ring, an O2-
independent reaction that liberates iron and produces the linear tetrapyrrole, anaerobilin …

Increasing antibiotic resistance, and a growing recognition of the importance of the human
microbiome, demand that new therapeutic targets be identified. Characterization of …

Uropathogenic Escherichia coli (UPEC) are the most common cause of urinary tract infection
(UTI). UPEC normally reside in the intestine, and during establishment of UTI, they undergo …

Fusobacterium nucleatum is an opportunistic oral pathogen that is associated with various
cancers. To fulfill its essential need for iron, this anaerobe will express heme uptake …