Emerging nanotechnology and advanced materials for cancer radiation therapy

G Song, L Cheng, Y Chao, K Yang, Z Liu - Advanced materials, 2017 - Wiley Online Library
Radiation therapy (RT) including external beam radiotherapy (EBRT) and internal
radioisotope therapy (RIT) has been widely used for clinical cancer treatment. However …

Gold nanoparticles for applications in cancer radiotherapy: Mechanisms and recent advancements

S Her, DA Jaffray, C Allen - Advanced drug delivery reviews, 2017 - Elsevier
Gold nanoparticles (AuNPs) have emerged as novel radiosensitizers owing to their high X-
ray absorption, synthetic versatility, and unique chemical, electronic and optical properties …

Low-dose X-ray radiotherapy–radiodynamic therapy via nanoscale metal–organic frameworks enhances checkpoint blockade immunotherapy

K Lu, C He, N Guo, C Chan, K Ni, G Lan… - Nature biomedical …, 2018 - nature.com
Checkpoint blockade immunotherapy relies on energized cytotoxic T cells attacking tumour
tissue systemically. However, for many cancers, the reliance on T cell infiltration leads to low …

The development of ruthenium (II) polypyridyl complexes and conjugates for in vitro cellular and in vivo applications

FE Poynton, SA Bright, S Blasco, DC Williams… - Chemical Society …, 2017 - pubs.rsc.org
Ruthenium (II)[Ru (II)] polypyridyl complexes have been the focus of intense investigations
since work began exploring their supramolecular interactions with DNA. In recent years …

The HPV E6/E7 oncogenes: key factors for viral carcinogenesis and therapeutic targets

K Hoppe-Seyler, F Bossler, JA Braun, AL Herrmann… - Trends in …, 2018 - cell.com
Human papillomavirus (HPV)-induced cancers are expected to remain a major health
problem worldwide for decades. The growth of HPV-positive cancer cells depends on the …

Chemophototherapy: an emerging treatment option for solid tumors

D Luo, KA Carter, D Miranda, JF Lovell - Advanced Science, 2017 - Wiley Online Library
Near infrared (NIR) light penetrates human tissues with limited depth, thereby providing a
method to safely deliver non‐ionizing radiation to well‐defined target tissue volumes. Light …

Poloxamer hydrogels for biomedical applications

E Russo, C Villa - Pharmaceutics, 2019 - mdpi.com
This review article focuses on thermoresponsive hydrogels consisting of poloxamers which
are of high interest for biomedical application especially in drug delivery for ophthalmic …

Gold nanoparticles in combinatorial cancer therapy strategies

J Beik, M Khateri, Z Khosravi, SK Kamrava… - Coordination Chemistry …, 2019 - Elsevier
Cancer is one of the most important health issues, which is the second leading cause of
death in the world. Conventional cancer therapy methods encounter with serious drawbacks …

Strategies for optimizing the response of cancer and normal tissues to radiation

EJ Moding, MB Kastan, DG Kirsch - Nature reviews Drug discovery, 2013 - nature.com
Approximately 50% of all patients with cancer receive radiation therapy at some point during
the course of their treatment, and the majority of these patients are treated with curative …

Clinical development of new drug–radiotherapy combinations

RA Sharma, R Plummer, JK Stock… - Nature reviews Clinical …, 2016 - nature.com
In countries with the best cancer outcomes, approximately 60% of patients receive
radiotherapy as part of their treatment, which is one of the most cost-effective cancer …