The development of HIV vaccines has been hampered by the lack of an animal model that
can accurately predict vaccine efficacy. Chimpanzees can be infected with HIV‐1 but are not …

Regulatory T cells (Tregs) have a dominant role in self‐tolerance and control of autoimmune
diseases. These cells also play a pivotal role in chronic viral infections and cancer by …

Optimal protective immunity to HIV will likely require that plasma cells, memory B cells and
memory T cells be stationed in mucosal tissues at portals of viral entry. Mucosal vaccine …

The development of a safe and effective preventive HIV-1 vaccine remains a public health
priority. Despite scientific difficulties and disappointing results, HIV-1 vaccine clinical …

Identifying immune correlates of protection is a major challenge in AIDS vaccine
development. Anti-Envelope antibodies have been considered critical for protection against …

Formation of immunological synapses (IS) between dendritic cells (DCs) and conventional
CD4+ T cells (Tcon) is critical for productive immune responses. However, when DCs are …

Chinese rhesus macaques (CRMs) are ideal experimental animals for studying the
pathogenesis of human immunodeficiency virus (HIV) and simian immunodeficiency virus …

An efficacious HIV vaccine is urgently needed to curb the AIDS pandemic. The modest
protection elicited in the phase III clinical vaccine trial in Thailand provided hope that this …

New directions for HIV vaccine development from animal model... : Current Opinion in HIV
and AIDS New directions for HIV vaccine development from animal models : Current …

Objective: Intravaginal exposure to simian immunodeficiency virus (SIV) acutely recruits
interferon-alpha (IFN-α) producing plasmacytoid dendritic cells (pDC) and CD4+ T …