The neuroprotective potentiality of flavonoids on Alzheimer's disease

A Calderaro, GT Patanè, E Tellone, D Barreca… - International journal of …, 2022 - mdpi.com
Alzheimer's disease (AD), due to its spread, has become a global health priority, and is
characterized by senile dementia and progressive disability. The main cause of AD and …

Natural polyphenols against neurodegenerative disorders: potentials and pitfalls

A Ebrahimi, H Schluesener - Ageing research reviews, 2012 - Elsevier
Within the last years, a rapidly growing number of polyphenolic compounds with
neuroprotective effects have been described. Many efforts have been made to explore the …

The entrancing role of dietary polyphenols against the most frequent aging‐associated diseases

MA Shah, HI Faheem, A Hamid… - Medicinal Research …, 2024 - Wiley Online Library
Aging, a fundamental physiological process influenced by innumerable biological and
genetic pathways, is an important driving factor for several aging‐associated disorders like …

Polyphenols as therapeutic molecules in Alzheimer's disease through modulating amyloid pathways

J Lakey-Beitia, R Berrocal, KS Rao, AA Durant - Molecular neurobiology, 2015 - Springer
Alzheimer's disease (AD) is a complex and multifactorial neurodegenerative condition. The
complex pathology of this disease includes oxidative stress, metal deposition, formation of …

The use of flavonoids in central nervous system disorders

C Grosso, P Valentão, F Ferreres… - Current medicinal …, 2013 - ingentaconnect.com
Neurodegenerative, neurological and psychiatric diseases are a group of pathologies with
huge social and economic impacts. Since brain disorders continue to be pathological …

Enzyme tunnels and gates as relevant targets in drug design

SM Marques, L Daniel, T Buryska… - Medicinal Research …, 2017 - Wiley Online Library
Many enzymes contain tunnels and gates that are essential to their function. Gates
reversibly switch between open and closed conformations and thereby control the traffic of …

Molecular level insight into the benefit of myricetin and dihydromyricetin uptake in patients with Alzheimer's diseases

M Liu, H Guo, Z Li, C Zhang, X Zhang… - Frontiers in Aging …, 2020 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disease with a high incidence rate and
complicated pathogenesis. Currently, all anti-AD drugs treat the symptoms of the disease …

Changing paradigm from one target one ligand towards multi-target directed ligand design for key drug targets of Alzheimer disease: an important role of in silico …

A Kumar, A Tiwari, A Sharma - Current Neuropharmacology, 2018 - ingentaconnect.com
Alzheimer disease (AD) is now considered as a multifactorial neurodegenerative disorder
and rapidly increasing to an alarming situation and causing higher death rate. One target …

Natural phenolic compounds as therapeutic and preventive agents for cerebral amyloidosis

M Yamada, K Ono, T Hamaguchi… - Natural compounds as …, 2015 - Springer
Epidemiological studies have suggested that diets rich in phenolic compounds may have
preventive effects on the development of dementia or Alzheimer's disease (AD). We …

Mitigating Alzheimer's disease with natural polyphenols: A review

R Gaudreault, N Mousseau - Current Alzheimer Research, 2019 - ingentaconnect.com
According to Alzheimer's Disease International (ADI), nearly 50 million people worldwide
were living with dementia in 2017, and this number is expected to triple by 2050. Despite …