Advances in biosynthesis, regulation, and metabolic engineering of plant specialized terpenoids

DA Nagegowda, P Gupta - Plant Science, 2020 - Elsevier
Plant specialized terpenoids are natural products that have no obvious role in growth and
development, but play many important functional roles to improve the plant's overall fitness …

Plant innate immune response: qualitative and quantitative resistance

AC Kushalappa, KN Yogendra… - Critical Reviews in Plant …, 2016 - Taylor & Francis
Plant diseases, caused by microbes, threaten world food, feed, and bioproduct security.
Plant resistance has not been effectively deployed to improve resistance in plants for lack of …

Natural withanolides, an update

G Xia, S Cao, L Chen, F Qiu - Natural Product Reports, 2022 - pubs.rsc.org
Covering: March 2010 to December 2020. Previous review: Nat. Prod. Rep., 2011, 28, 705
This review summarizes the latest progress and perspectives on the structural classification …

A WRKY transcription factor from Withania somnifera regulates triterpenoid withanolide accumulation and biotic stress tolerance through modulation of phytosterol …

AK Singh, SR Kumar, V Dwivedi, A Rai, S Pal… - New …, 2017 - Wiley Online Library
Withania somnifera produces pharmacologically important triterpenoid withanolides that are
derived via phytosterol pathway; however, their biosynthesis and regulation remain to be …

Cross-kingdom small RNAs among animals, plants and microbes

J Zeng, VK Gupta, Y Jiang, B Yang, L Gong, H Zhu - Cells, 2019 - mdpi.com
Small RNAs (sRNAs), a class of regulatory non-coding RNAs around 20~ 30-nt long,
including small interfering RNAs (siRNAs) and microRNAs (miRNAs), are critical regulators …

Endophyte-mediated modulation of defense-related genes and systemic resistance in Withania somnifera (L.) Dunal under Alternaria alternata stress

A Mishra, SP Singh, S Mahfooz, SP Singh… - Applied and …, 2018 - Am Soc Microbiol
Endophytes have been explored and found to perform an important role in plant health.
However, their effects on the host physiological function and disease management remain …

Integrated transcriptomic and metabolomic analysis reveals the molecular basis of tissue-specific accumulation of bioactive steroidal alkaloids in Fritillaria …

H Liao, H Quan, B Huang, H Ji, T Zhang, J Chen… - Phytochemistry, 2023 - Elsevier
Fritillaria unibracteata is an endangered medicinal plant whose bulb has been used as a
Chinese herb to suppress cough, asthma and excessive phlegm for centuries. Steroidal …

Endophytes of Withania somnifera modulate in planta content and the site of withanolide biosynthesis

SS Pandey, S Singh, H Pandey, M Srivastava, T Ray… - Scientific reports, 2018 - nature.com
Tissue specific biosynthesis of secondary metabolites is a distinguished feature of medicinal
plants. Withania somnifera, source of pharmaceutically important withanolides …

Molecular characterization of three CYP450 genes reveals their role in withanolides formation and defense in Withania somnifera, the Indian Ginseng

HB Shilpashree, SJ Sudharshan, AK Shasany… - Scientific Reports, 2022 - nature.com
The medicinal properties of Ashwagandha (Withania somnifera) are attributed to triterpenoid
steroidal lactones, withanolides, which are proposed to be derived from phytosterol …

Two CYP716A subfamily cytochrome P450 monooxygenases of sweet basil play similar but nonredundant roles in ursane‐and oleanane‐type pentacyclic triterpene …

RC Misra, S Sharma, Sandeep, A Garg… - New …, 2017 - Wiley Online Library
The medicinal plant sweet basil (Ocimum basilicum) accumulates bioactive ursane‐and
oleanane‐type pentacyclic triterpenes (PCT s), ursolic acid and oleanolic acid, respectively …