Acquisition of the ability to evade cellular suicide, or apoptosis, is one of the master switches
that contributes to cellular transformation and, ultimately, to invasive cancer. Much has been …

Survivin, a member of the family of inhibitor of apoptosis proteins, functions as a key
regulator of mitosis and programmed cell death. Initially, survivin was described as an …

Background Malignant glioma is the most common and lethal primary brain tumour, with
dismal survival rates and no effective treatment. We examined the safety and activity of NSC …

PURPOSE Despite intensive treatment with surgery, radiation therapy, temozolomide (TMZ)
chemotherapy, and tumor-treating fields, mortality of newly diagnosed glioblastoma (nGBM) …

Survivin is a member of the inhibitor of apoptosis (IAP) gene family that has attracted
attention from several viewpoints of basic and translational research. Its cell cycle-regulated …

2014-11-12 Assigned to IMMATICS BIOTECHNOLOGIES GMBH reassignment IMMATICS
BIOTECHNOLOGIES GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …

Survivin, an inhibitor of apoptosis protein, is highly expressed in most cancers and
associated with chemotherapy resistance, increased tumor recurrence, and shorter patient …

Survival for patients with glioblastoma, the most common high-grade primary CNS tumor,
remains poor despite multiple therapeutic interventions including intensifying cytotoxic …

Survivin is a 16.5 kDa protein overexpressed in almost all malignancies but rarely detected
in normal differentiated adult tissues. Functionally, survivin has been shown to inhibit …

Nucleic acid drugs have the advantages of rich target selection, simple in design, good and
enduring effect. They have been demonstrated to have irreplaceable superiority in brain …