The calcium-sensing receptor (CaSR) is a class CG protein–coupled receptor that responds
to multiple endogenous agonists and allosteric modulators, including divalent and trivalent …

On the cellular level, osteoporosis (OP) is a result of imbalanced bone remodeling, in which
osteoclastic bone resorption outcompetes osteoblastic bone formation. Currently available …

Calcium-sensing receptor (CaSR) is a class CG protein–coupled receptor (GPCR) that plays
an important role in calcium homeostasis and parathyroid hormone secretion. Here, we …

The human extracellular calcium-sensing (CaS) receptor controls plasma Ca2+ levels and
contributes to nutrient-dependent maintenance and metabolism of diverse organs. Allosteric …

The CaSR is a class CG protein-coupled receptor (GPCR) that acts as a multimodal
chemosensor to maintain diverse homeostatic functions. The CaSR is a clinical therapeutic …

The stomach is the primary source of the orexigenic and adiposity-promoting hormone,
ghrelin. There is emerging evidence on the nutrient-mediated modulation of gastric ghrelin …

Calcium-sensing receptors (CaSRs) play a central role in regulating extracellular calcium
(Ca 2+) homeostasis and many (patho) physiological processes. This regulation is primarily …

Abstract The Ca 2+-sensing receptor (CaSR) is a G-protein-coupled receptor activated by
elevated concentrations of extracellular Ca 2+, and was initially known for its regulation of …

The calcium‐sensing receptor (CaSR) is a clinical target in the treatment of
hyperparathyroidism and related diseases. However, clinical use of approved CaSR …

Asthma is a heterogeneous chronic airway disease with an unmet need for improved
therapeutics in uncontrolled severe disease. The calcium-sensing receptor (CaSR) is a G …