Cytosolic protein delivery offers opportunities to develop protein-based therapeutics
specifically modulate intracellular processes, especially those linked to 'undruggable'targets …

Optimizing synthetic nanocarriers is like searching for a needle in a haystack. How to find
the most suitable carrier for intracellular delivery of a specified macromolecular nanoagent …

Direct delivery of proteins into cells avoids many drawbacks of gene delivery, and thus has
emerging applications in biotherapy. However, it remains a challenging task owing to limited …

The efficient delivery of biopharmaceutical drugs such as proteins and peptides into the
cytosol of target cells poses substantial challenges owing to their large size and …

Functionalized trialkoxysilanes are widely used to modify the surface properties of materials
and devices. It will be shown that the photoinitiated radical-based thiol–ene “click” reaction …

Self-assembly of individual units into multicomponent complexes is a powerful approach for
the generation of functional superstructures. We present the coordinative interaction of …

CRISPR-Cas9 is a central focus of the emerging field of gene editing and photodynamic
therapy (PDT) is a clinical-stage ablation modality combining photosensitizers with light …

Cell-penetrating peptides (CPPs) are promising tools for the intracellular delivery of various
biological payloads. However, the impact of payload conjugation on the cell-penetrating …

Alkaline phosphatase (ALP) enables intracellular targeting by peptide assemblies, but how
the ALP substrates enter cells remains elusive. Here we show that nanoscale …

Significance: Nucleic acids such as gene-encoding DNAs, gene-silencing small interfering
RNAs, or recombinant proteins addressing intracellular molecular targets present a major …