Spatial navigation deficits—overlooked cognitive marker for preclinical Alzheimer disease?
G Coughlan, J Laczó, J Hort, AM Minihane… - Nature Reviews …, 2018 - nature.com
Detection of incipient Alzheimer disease (AD) pathophysiology is critical to identify
preclinical individuals and target potentially disease-modifying therapies towards them …
preclinical individuals and target potentially disease-modifying therapies towards them …
Explaining world‐wide variation in navigation ability from millions of people: citizen science project sea hero quest
Navigation ability varies widely across humans. Prior studies have reported that being
younger and a male has an advantage for navigation ability. However, these studies have …
younger and a male has an advantage for navigation ability. However, these studies have …
Toward personalized cognitive diagnostics of at-genetic-risk Alzheimer's disease
Spatial navigation is emerging as a critical factor in identifying preclinical Alzheimer's
disease (AD). However, the impact of interindividual navigation ability and demographic risk …
disease (AD). However, the impact of interindividual navigation ability and demographic risk …
Differentiation of mild cognitive impairment using an entorhinal cortex-based test of virtual reality navigation
D Howett, A Castegnaro, K Krzywicka, J Hagman… - Brain, 2019 - academic.oup.com
The entorhinal cortex is one of the first regions to exhibit neurodegeneration in Alzheimer's
disease, and as such identification of entorhinal cortex dysfunction may aid detection of the …
disease, and as such identification of entorhinal cortex dysfunction may aid detection of the …
Egocentric and allocentric spatial memory in mild cognitive impairment with real-world and virtual navigation tasks: A systematic review
Background: Spatial navigation is the ability to estimate one's position on the basis of
environmental and self-motion cues. Spatial memory is the cognitive substrate underlying …
environmental and self-motion cues. Spatial memory is the cognitive substrate underlying …
Going round in circles—The Papez circuit in Alzheimer's disease
G Forno, A Lladó, M Hornberger - European Journal of …, 2021 - Wiley Online Library
The hippocampus is regarded as the pivotal structure for episodic memory symptoms
associated with Alzheimer's disease (AD) pathophysiology. However, what is often …
associated with Alzheimer's disease (AD) pathophysiology. However, what is often …
The effect of Alzheimer's disease on spatial navigation strategies
Hippocampal and basal forebrain (BF) atrophy is associated with allocentric navigation
impairment in Alzheimer's disease (AD) and may lead to recruitment of compensatory …
impairment in Alzheimer's disease (AD) and may lead to recruitment of compensatory …
[HTML][HTML] An immersive virtual reality platform for assessing spatial navigation memory in predementia screening: feasibility and usability study
Background: Traditional methods for assessing memory are expensive and have high
administrative costs. Memory assessment is important for establishing cognitive impairment …
administrative costs. Memory assessment is important for establishing cognitive impairment …
Exploring the contribution of spatial navigation to cognitive functioning in older adults
Spatial navigation (SN) impairment is present early in Alzheimer's disease (AD). We tested
whether SN performance, self-centered (egocentric) and world-centered (allocentric), was …
whether SN performance, self-centered (egocentric) and world-centered (allocentric), was …
Two immersive virtual reality tasks for the assessment of spatial orientation in older adults with and without cognitive impairment: concurrent validity, group comparison …
Objective: Spatial disorientation is common in Alzheimer's disease (AD), Mild Cognitive
Impairment (MCI), and preclinical individuals with AD biomarkers. However, traditional …
Impairment (MCI), and preclinical individuals with AD biomarkers. However, traditional …