Uncovering the underworld of axial spondyloarthritis

S Del Vescovo, V Venerito, C Iannone… - International journal of …, 2023 - mdpi.com
Axial spondyloarthritis (axial-SpA) is a multifactorial disease characterized by inflammation
in sacroiliac joints and spine, bone reabsorption, and aberrant bone deposition, which may …

The molecular mechanism of neutrophil extracellular traps and its role in bone and joint disease

M Xiang, M Yin, S Xie, L Shi, W Nie, B Shi, G Yu - Heliyon, 2023 - cell.com
As the body's first line of defense, neutrophils play an important role in the early stages of
infection. Neutrophil extracellular traps (NETs), a novel way to kill pathogens, are released …

Comprehensive analysis of differentially expressed mRNA and circRNA in Ankylosing spondylitis patients' platelets

T Wang, S Meng, P Chen, L Wei, C Liu, D Tang… - Experimental Cell …, 2021 - Elsevier
Ankylosing spondylitis (AS) is a chronic inflammatory disease significantly decreasing the
quality of life. Platelets play an important and active role in the development of AS …

Exploring causal correlations between inflammatory cytokines and ankylosing spondylitis: a bidirectional mendelian-randomization study

P Fang, X Liu, Y Qiu, Y Wang, D Wang, J Zhao… - Frontiers in …, 2023 - frontiersin.org
Background The impact of inflammatory factors on the development of Ankylosing
Spondylitis (AS) is widely recognized, but the exact causal relationship remains unclear …

Dry and wet experiments reveal diagnostic clustering and immune landscapes of cuproptosis patterns in patients with ankylosing spondylitis

P Zhang, H Chen, Y Zhang, Y Liu, G Zhu… - International …, 2024 - Elsevier
Cuproptosis is a new manner of mitochondrial cell death induced by copper. There is
evidence that serum copper has a crucial impact on ankylosing spondylitis (AS) by copper …

Analysis of m6A regulators related immune characteristics in ankylosing spondylitis by integrated bioinformatics and computational strategies

D Guo, J Liu, S Li, P Xu - Scientific Reports, 2024 - nature.com
Abstract N6-methyladenosine (m6A) modification, as a common epigenetic modification, has
been widely studied in autoimmune diseases. However, the role of m6A in the regulation of …

Investigating the Molecular Mechanism of Qianghuo Shengshi Decoction in the Treatment of Ankylosing Spondylitis Based on Network Pharmacology and Molecular …

S Luo, X Xiao, W Luo, X Zhang, J Zhang, S Tang - Processes, 2022 - mdpi.com
Background: Qianghuo Shengshi decoction (QHSSD), a traditional Chinese medicine
formula, is used to treat ankylosing spondylitis (AS) in China. The pharmacological …

Immune mechanism of low bone mineral density caused by ankylosing spondylitis based on bioinformatics and machine learning

D Zhang, J Liu, B Gao, Y Zong, X Guan, F Zhang… - Frontiers in …, 2022 - frontiersin.org
Background and Objective: This study aims to find the key immune genes and mechanisms
of low bone mineral density (LBMD) in ankylosing spondylitis (AS) patients. Methods: AS …

[HTML][HTML] Application of neutrophil to lymphocyte ratio in ankylosing spondylitis: Based on bibliometric and visualization analysis

C Chengzhi, L Jian, H Yuedi, L Yang, C Yiming, H Dan - Medicine, 2024 - journals.lww.com
Ankylosing spondylitis (AS) as a autoimmune disease involves inflammatory responses in
the development of the disease, often causing changes in the neutrophil to lymphocyte ratio …

[HTML][HTML] Beyond the horizon: Innovations and future directions in axial-spondyloarthritis

V Venerito, S Del Vescovo, G Lopalco… - Archives of …, 2023 - ncbi.nlm.nih.gov
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease of the spine and sacroiliac
joints. This review discusses recent advances across multiple scientific fields that promise to …