Solid lipid nanoparticles (SLNs), the spheroidal-shaped, colloids state lipophilic-natured,
innovative nanoscale particulate materials, are being concurrently prepared by the quality …

The successful development of nonviral delivery systems for nucleic acids has been
reported extensively over the past years. Increasingly employed to improve the delivery …

Uncontrolled inflammation is responsible for acute and chronic diseases in the lung.
Regulating expression of pro-inflammatory genes in pulmonary tissue using small interfering …

Thermostable dry powder inhaler (DPI) formulations with high aerosol performance are
attractive inhalable solid dosage forms for local treatment of inflammatory lung diseases. We …

In recent years, RNA-based therapies have gained much attention as biomedicines due to
their remarkable therapeutic effects with high specificity and potency. Lung diseases offer a …

We analyzed the structural and material properties of small interfering RNA (siRNA)-loaded
lipid-polymer hybrid nanoparticles (LPNs) containing ionizable lipidoid and poly (dl-lactic-co …

Nanomedicines based on nanoparticles rely both on the potency of the drug as well as the
efficiency of the delivery system, for which particle size plays a crucial role. For the …

Abstract Background The Target Product Profile (TPP) is a tool used in industry to guide
development strategies by addressing user needs and fostering effective communication …

Pulmonary delivery of small interfering RNA (siRNA) using nanoparticle-based delivery
systems is promising for local treatment of respiratory diseases. We designed dry powder …

Uncontrolled inflammation is the driver of numerous lung diseases. Current treatments,
including corticosteroids and bronchodilators, can be effective. However, they often come …