New insights into activation and function of the AMPK

GR Steinberg, DG Hardie - Nature reviews Molecular cell biology, 2023 - nature.com
The classical role of AMP-activated protein kinase (AMPK) is as a cellular energy sensor
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …

AMPK: sensing glucose as well as cellular energy status

SC Lin, DG Hardie - Cell metabolism, 2018 - cell.com
Mammalian AMPK is known to be activated by falling cellular energy status, signaled by
rising AMP/ATP and ADP/ATP ratios. We review recent information about how this occurs …

CLC chloride channels and transporters: structure, function, physiology, and disease

TJ Jentsch, M Pusch - Physiological reviews, 2018 - journals.physiology.org
CLC anion transporters are found in all phyla and form a gene family of eight members in
mammals. Two CLC proteins, each of which completely contains an ion translocation …

AMPK: a nutrient and energy sensor that maintains energy homeostasis

DG Hardie, FA Ross, SA Hawley - Nature reviews Molecular cell biology, 2012 - nature.com
AMP-activated protein kinase (AMPK) is a crucial cellular energy sensor. Once activated by
falling energy status, it promotes ATP production by increasing the activity or expression of …

AMPK activators: mechanisms of action and physiological activities

J Kim, G Yang, Y Kim, J Kim, J Ha - Experimental & molecular medicine, 2016 - nature.com
AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis, which
coordinates metabolic pathways and thus balances nutrient supply with energy demand …

Molecular mechanisms of mucormycosis—The bitter and the sweet

C Baldin, AS Ibrahim - PLoS pathogens, 2017 - journals.plos.org
During the past 2 decades, mucormycosis has become the third most common invasive
fungal infection in patients with hematological malignancies and organ transplantations [1] …

Structural and functional comparison of magnesium transporters throughout evolution

GAC Franken, MA Huynen, LA Martínez-Cruz… - Cellular and Molecular …, 2022 - Springer
Abstract Magnesium (Mg2+) is the most prevalent divalent intracellular cation. As co-factor in
many enzymatic reactions, Mg2+ is essential for protein synthesis, energy production, and …

Methionine metabolism and liver disease

JM Mato, ML Martínez-Chantar, SC Lu - Annu. Rev. Nutr., 2008 - annualreviews.org
In the early 1930s, Banting and Best, the discoverers of insulin, found that choline could
prevent the development of fatty liver disease (steatosis) in pancreatectomized dogs treated …

CLC chloride channels and transporters: from genes to protein structure, pathology and physiology

TJ Jentsch - Critical reviews in biochemistry and molecular biology, 2008 - Taylor & Francis
ABSTRACT CLC genes are expressed in species from bacteria to human and encode Cl−-
channels or Cl−/H+-exchangers. CLC proteins assemble to dimers, with each monomer …

Anion channels/transporters in plants: from molecular bases to regulatory networks

H Barbier-Brygoo, A De Angeli, S Filleur… - Annual review of …, 2011 - annualreviews.org
Anion channels/transporters are key to a wide spectrum of physiological functions in plants,
such as osmoregulation, cell signaling, plant nutrition and compartmentalization of …