Here we review the emerging neurobiological understanding of the role of the brain's reward
system in the regulation of body weight in health and in disease. Common obesity is …

Ann Kelley was a scientific pioneer in reward neuroscience. Her many notable discoveries
included demonstrations of accumbens/striatal circuitry roles in eating behavior and in food …

Appetite suppression occurs after a meal and in conditions when it is unfavourable to eat,
such as during illness or exposure to toxins. A brain region proposed to play a role in …

Neurons in the arcuate nucleus that produce AgRP, NPY, and GABA (AgRP neurons)
promote feeding. Ablation of AgRP neurons in adult mice results in Fos activation in …

Oral sensory signals drive dietary fat intake, but the neural mechanisms underlying this
process are largely unknown. The endocannabinoid system has gained recent attention for …

The neural basis of food sensory pleasure has become an increasingly studied topic in
neuroscience and psychology. Progress has been aided by the discovery of localized brain …

Conditioned taste aversion (CTA) is a phenomenon in which an individual forms an
association between a novel tastant and toxin-induced gastrointestinal malaise. Previous …

The endocannabinoid system in the brain and periphery plays a major role in controlling
food intake and energy balance. We reported that tasting dietary fats was met with increased …

Endocannabinoids such as anandamide [N-arachidonoylethanolamine (AEA)] and 2-
arachidonoyl glycerol (2-AG) are known orexigenic mediators that act via CB1 receptors in …

The circuit mechanisms underlying fear-induced suppression of feeding are poorly
understood. To help fill this gap, mice were fear conditioned, and the resulting changes in …