Recent studies have suggested a role for epigenetic mechanisms in the complex etiology of
various neurodegenerative diseases. In this review, we discuss advances that have been …

Methylation of cytosine at the 5-position is a common epigenetic modification in mammalian
DNA and plays an important role in regulating gene expression. Oxidized derivatives of 5 …

Abstract Background Late-onset Alzheimer's disease (AD) is a complex multifactorial
affliction, the pathogenesis of which is thought to involve gene-environment interactions that …

Nucleic acids, especially RNA, naturally contain a diversity of chemically modified
nucleosides. To understand the biological role of these modified nucleosides, nucleic acid …

An unusual protocol for a “one-pot” three-step reaction to build a 2, 4, 9-triazaadamantane
skeleton from triallylcarbinol was developed. The design and execution of these tactics are …

In the era of precision oncology, identifying abnormal genetic and epigenetic alterations has
transformed the way cancer is diagnosed, managed, and treated. 5-hydroxymethylcytosine …

Cellular DNA and RNA are decorated with diverse chemical modifications, which add new
layers to gene regulation and play crucial roles across development and disease …

The mixture of copper (II) perchlorate and 2, 2, 6, 6-tetramethylpiperidine-1-oxyl (TEMPO)
mildly and specifically oxidized 5-hydroxymethylcytosine to yield 5-formylcytosine because …

Hydroxymethylcytosine (5hmC), an intermediate product of DNA demethylation, is important
for the regulation of gene expression during development and even tumorigenesis. The …

Polynitroazaadamantanes have a broad application prospect in the field of energetic
materials. Herein, the synthesis of 2, 4, 4, 8, 8‐pentanitro‐2‐azaadamantane, a new …