The fluorescence of organic molecules depends sensitively on their environment.
Fluorescent dyes have accordingly become popular molecular probes not only to determine …

Noncovalent, extrinsic fluorescent dyes are applied in various fields of protein analysis, eg to
characterize folding intermediates, measure surface hydrophobicity, and detect aggregation …

Because understanding amyloid fibrillation in molecular detail is essential for development
of strategies to control amyloid formation and overcome neurodegenerative disorders …

Thioflavin-T (ThT) can bind to amyloid fibrils and is frequently used as a fluo-rescent marker
for in vitro biomedical assays of the potency of inhibitors for amyloid-related diseases, such …

The effect of solvent viscosity on thioflavin T (ThT) fluorescent properties is analyzed to
understand the molecular mechanisms of the characteristic increase in ThT fluorescence …

Quantum-chemical calculations of the Thioflavin T (ThT) molecule in the ground S0 and first
excited singlet S1 states were carried out. It has been established that ThT in the ground …

Aggregation and subsequent development of protein deposition diseases originate from
conformational changes in corresponding amyloidogenic proteins. The accumulated data …

In this work, the fluorescence of thioflavin T (ThT) was studied in a wide range of viscosity
and temperature. It was shown that ThT fluorescence quantum yield varies from 0.0001 in …

We report an intriguing noncovalent interaction of thioflavin T (ThT), a fibril diagnostic dye,
with the versatile macrocyclic host molecule cucurbit [7] uril (CB7) in the presence of metal …

The misfolding and aggregation of proteins into amyloid fibrils characterizes many
neurodegenerative disorders such as Parkinson's and Alzheimer's diseases. We report here …