Rheumatoid arthritis (RA) is characterized by inflammation and destruction of bone and
cartilage in affected joints. Autoimmune responses lead to increased osteoclastic bone …

Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease
progression leads to joint deformity and associated loss of function, which significantly …

Increased osteoclast (OC) differentiation and activity is the critical event that results in bone
loss and joint destruction in common pathological bone conditions, such as osteoporosis …

Bone erosion is a central feature of rheumatoid arthritis and is associated with disease
severity and poor functional outcome. Erosion of periarticular cortical bone, the typical …

Bone is a tissue undergoing continuous building and degradation. This remodelling is a
tightly regulated process that can be disturbed by many factors, particularly hormonal …

Rheumatoid arthritis is the most common inflammatory arthritis and is a major cause of
disability. It existed in early Native American populations several thousand years ago but …

The adult skeleton regenerates by temporary cellular structures that comprise teams of
juxtaposed osteoclasts and osteoblasts and replace periodically old bone with new. A …

Cytokines regulate a broad range of inflammatory processes that are implicated in the
pathogenesis of rheumatoid arthritis. In rheumatoid joints, it is well known that an imbalance …

Progress has been made in the application of nanomedicine in rheumatoid arthritis (RA)
treatment. However, the whole process of monitoring and treatment of RA remains a …

Osteoimmunology is an interdisciplinary research field focused on the molecular
understanding of the interplay between the immune and skeletal systems. Although …