Pyrimidine heterocycles are proven to be biologically active heterocycles, found in many
biological systems, displaying a broad spectrum of biological activities including anticancer …

This review provides a detailed survey of the present literature data on β-alkoxyvinyl-and β-
enaminocarbonyl compounds as CCC bis-electrophiles in reactions with the common NCN …

Targeted covalent inhibitors (TCIs) directing cysteine have historically relied on a narrow set
of electrophilic “warheads”. While Michael acceptors remain at the forefront of TCI design …

An efficient approach to the preparation of pyridine carboxylates fused with 5-or 6-
membered heteroaromatic rings is described. The method relied on the Combes-type …

An approach was developed for the synthesis of polyfunctionalized pyrimidines based on
analogs of 1, 2, 4-triketones. Acetal-substituted β-diketones are involved in the condensation …

Reactions of five-and six-membered cyclic β-alkoxyvinyl α-keto esters and NCC-
binucleophiles are described. The following binucleophiles were studied: heteroaromatic …

Found in natural products, and frequently used as flavoring agents or as building blocks for
pharmaceuticals, diazines and their benzo derivatives possess a diverse set of properties …

The synthetic versatility of ethyl 2-(2-ethoxy-3, 4-dihydro-2H-pyran-5-yl)-2-oxoacetate for the
synthesis of ethyl 2-oxo-2-(1-alkyl/aryl-6-(amino/ethoxy)-1, 4, 5, 6-tetrahydropyridin-3-yl) …

The 1, 4-dicarbonyl scaffold ethyl 3-formyl-4, 5-dihydrofuran-2-carboxylate was obtained
through the rearrangement of the parent ethyl 2-(4, 5-dihydrofuran-3-yl)-2-oxoacetate and …

Aim. To study the use of chloromethyl trimethylsilylmethyl sulfide as a precursor of
thiocarbonyl ylide in [3+ 2] cycloaddition reaction to a number of α, β-unsaturated …