Halofuginone is an analog of febrifugine—an alkaloid originally isolated from the plant
Dichroa febrifuga. During recent years, halofuginone has attracted much attention because …

Mesenchymal stem cells (MSCs) are considered to be a powerful tool in the treatment of
various diseases. Scientists are particularly interested in the possibility of using MSCs in …

Quinazolinones are a diverse group of nitrogen-containing heterocyclic compounds with
promising antimalarial and antileishmanial activities. Herein, some 3-aryl-2-styryl substituted …

An efficient, one-pot, two-step, four-component reaction for the synthesis of
spiroindoloquinazoline derivatives in the presence of 1, 4-diazabicyclo [2.2. 2] octane …

A simple and efficient domino protocol for the selective synthesis of 4-difluoromethyl and 4-
fluoromethyl quinazolin (thi) ones was established from readily available 2 …

Cancer is a disease characterized by genetic or epigenetic alterations in somatic cells that
result in uncontrolled cell growth and spread to other regions of the body. They are one type …

The utilization of the heterogeneous catalysts has become a vital way in organic synthesis
and the production of the desired product with a higher yield more than the traditional …

Abstract Reaction of 4, 6-dimethyl-3-cyanopyridine-2 (1 H)-thione (IIIa) or 4, 5, 6-
trisubstituted-3-cyanopyridine-2 (1 H)-thiones (IIIb–d) with 2-chloromethylquinazoline-4 (3 …

Malaria is a potentially life-threatening disease that affects millions worldwide, especially in
Sub-Saharan Africa. The recent emergence and spread of multidrug resistance in parts of …

In this study, several quantum mechanical-based computational approaches have been
used in order to propose accurate protocols for predicting the pK a's of quinazoline …