Apolipoprotein E (APOE) traffics lipids in the central nervous system. The E4 variant of APOE
is a major genetic risk factor for Alzheimer's disease (AD) and a multitude of other …

Background: There are now significant evidences that lipid metabolism is affected in
numerous neurodegenerative diseases including Alzheimer's disease. These dysfunctions …

Summary Loss-of-function (LOF) variants of TREM2, an immune receptor expressed in
microglia, increase Alzheimer's disease risk. TREM2 senses lipids and mediates myelin …

Abstract Changes to lipid metabolism are tightly associated with the onset and pathology of
Alzheimer's disease (AD). Lipids are complex molecules comprising many isomeric and …

Lipid metabolism is fundamental for brain development and function, but its roles in normal
and pathological neural stem cell (NSC) regulation remain largely unexplored. Here, we …

The defining features of Alzheimer's disease (AD) include alterations in protein aggregation,
immunity, lipid metabolism, synapses, and learning and memory. Of these, lipid …

Nervonic acid (NA) has attracted considerable attention because of its close relationship
with brain development. Sources of NA include oil crop seeds, oil-producing microalgae …

Alzheimer's disease (AD) is the most common age-related form of dementia, associated with
deposition of intracellular neuronal tangles consisting primarily of hyperphosphorylated …

Alzheimer's disease (AD) is an irreversible, progressive brain disease and can be
definitively diagnosed after death through an examination of senile plaques and …

A large body of research has demonstrated that human stearoyl-CoA desaturase 1 (SCD1),
a universally expressed fatty acid Δ9-desaturase that converts saturated fatty acids (SFA) …