The asserted dominant role of the kidneys in the chronic regulation of blood pressure and in
the etiology of hypertension has been debated since the 1970s. At the center of the theory is …

This study develops a lumped cardiovascular–respiratory system-level model that
incorporates patient-specific data to predict cardiorespiratory response to hypercapnia …

Short-term cardiovascular responses to head-up tilt (HUT) involve complex cardiovascular
regulation in order to maintain blood pressure at homoeostatic levels. This manuscript …

Two models describing the afferent baroreceptor firing are analyzed, a basic model
predicting firing using a single nonlinear differential equation, and an extended model …

The cardiovascular control system is continuously engaged to maintain homeostasis, but it is
known to fail in a large cohort of patients suffering from orthostatic intolerance. Numerous …

This study considers a 1D fluid dynamics arterial network model with 14 vessels developed
to assimilate ex vivo 0D temporal data for pressure-area dynamics in individual vessel …

Applying complex mathematical models of physiological systems is challenging due to the
large number of parameters. Identifying these parameters through experimentation is …

The parameter identification problem attempts to find parameter values that cause the
solution of a predictive model to match data. In this work, parameters in cardiovascular and …

Using mathematical models of physiological systems in medicine has allowed for the
development of diagnostic, treatment, and medical educational tools. However, their …

In this paper we examine a cardiovascular-respiratory model of mid-level complexity
designed to predict the dynamics of end-tidal carbon dioxide (CO 2) and cerebral blood flow …