The blood–brain barrier, which is formed by the endothelial cells that line cerebral
microvessels, has an important role in maintaining a precisely regulated microenvironment …

The epithelial and endothelial barriers of the human body are major obstacles for drug
delivery to the systemic circulation and to organs with unique environment and homeostasis …

The majority of brain metastases originate from lung cancer, breast cancer and malignant
melanoma. In order to reach the brain, parenchyma metastatic cells have to transmigrate …

The blood-brain barrier (BBB) is the one of the most robust physical barriers in the body,
comprised of tight junction (TJ) proteins in brain microvascular endothelial cells. The need …

The Src family of protein kinases (SFK) plays key roles in regulating fundamental cellular
processes, including cell growth, differentiation, cell shape, migration, and survival, and …

Prostate cancer is the most frequently diagnosed cancer in American men. We have
previously demonstrated that Src mediates androgen-independent proliferation in prostate …

Nasal administration has been proposed as a potential approach for the delivery of drugs to
the central nervous system. Ribavirin (RBV), an antiviral drug potentially useful to treat viral …

Neuroimaging of exogenous tracer extravasation has become the technique of choice in
preclinical and clinical studies of blood–brain barrier permeability. Such tracers have a …

Aging is associated with chronic inflammation partly mediated by increased levels of
damage-associated molecular patterns, which activate pattern recognition receptors (PRRs) …

Basolateral condition of the brain microvascular endothelium is believed to influence blood–
brain barrier (BBB) phenotype, although the precise transcriptional and post-translational …