Population movements have turned Chagas disease (CD) into a global public health
problem. Despite the successful implementation of subregional initiatives to control vectorial …

Methods for the diagnosis of infectious diseases have stagnated in the last 20–30 years.
Few major advances in clinical diagnostic testing have been made since the introduction of …

Background Most current guidelines recommend two serological tests to diagnose chronic
Chagas disease. When serological tests are persistently inconclusive, some guidelines …

Methods for the diagnosis of parasitic infections have stagnated in the past three decades.
Labor-intensive methods such as microscopy still remain the mainstay of several diagnostic …

Background. According to an estimate from the Centers for Disease Control and Prevention
(CDC), Chagas disease (CD) may affect 1.31% of Latin American immigrants in the United …

The cysteine protease cruzipain is essential for the viability, infectivity, and virulence of
Trypanosoma cruzi, the causative agent of Chagas disease. Thus, inhibitors of cruzipain are …

T. cruzi has a complex life cycle involving four developmental stages namely, epimastigotes,
metacyclic trypomastigotes, amastigotes and bloodstream trypomastigotes. Although …

Chagas disease has spread to areas that are nonendemic for the disease with human
migration. Since no single reference standard test is available, serological diagnosis of …

Apoptosis is a well-defined cellular process in which a cell dies, characterized by cell
shrinkage and DNA fragmentation. In parasites like Leishmania, the process of apoptosis …

Trypanosoma cruzi is the causal agent of Chagas' disease which affects millions of people
around the world mostly in Central and South America. T. cruzi expresses a wide variety of …