Privileged structures have been widely used as an effective template in medicinal chemistry
for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring …

The practice of polypharmacology is not a new concept but the approaches which are being
adopted for administering the two or more drugs together are varied from time to time …

Chalcones represent key structural motif in the plethora of biologically active molecules
including synthetic and natural products. Synthetic manipulations of chalcones or their …

Chalcones (1, 3-diaryl-2-propen-1-ones) and their heterocyclic analogues, belong to the
flavonoid family, which possess a number of interesting biological properties such as …

Naturally occurring coumarins, having wide spectrum of activities such as antioxidant, anti-
inflammatory, anticancer, MAO-B inhibitory and antimicrobial, are frequently used by the …

Pollutants from industry and chemical laboratories have harmful effects on human health
and the environment. Concerns about this problem have led to the development of more …

Numerous research reports have indicated the coumarin nucleus as a potential candidate
for development of anti-inflammatory drugs. Various phytoconstituents such as …

Dietary flavonoids, which occur in many plant foods, are considered as the most active
constituents among the plant-derived ones in vitro and in vivo. To date, many studies have …

Abstract Chalcones (1, 3-Diphenyl-2-propen-1-one) consist of a three carbon α, β-
unsaturated carbonyl system and act as precursors for the biosynthesis of flavonoids in …

A new series of chalcone–coumarin derivatives (9–19) linked by the 1, 2, 3-triazole ring
were synthesized through the azide/alkyne dipolar cycloaddition. Hybrid molecules were …