It is widely accepted that senescent cells accumulate with aging. They are characterized by
replicative arrest and the release of a myriad of factors commonly called the senescence …

Aging is a biological feature that is characterized by gradual degeneration of function in
cells, tissues, organs, or an intact organism due to the accumulation of environmental factors …

The global incidence of obesity and its comorbidities continues to rise along with a demand
for novel therapeutic interventions. Brown adipose tissue (BAT) is attracting attention as a …

The study of genes mutated in human disease often leads to new insights into biology as
well as disease mechanisms. One such gene is Wilms' tumour 1 (WT1), which plays multiple …

Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone
receptor family. Three different isoforms, PPAR alpha, PPAR beta/delta and PPAR gamma …

Formation of the coronary vasculature is a complex and precisely coordinated
morphogenetic process that begins with the formation of epicardium. The epicardium gives …

Glioblastoma (GBM) is the most frequent and aggressive primary brain tumor in adults, and
despite advances in neuro-oncology, the prognosis for patients remains dismal. The signal …

Phosphofructo 2-kinase/fructose 2, 6-bisphosphatase 3 (PFKFB3) has been reported to be
overexpressed in human cancer tissues and to promote the proliferation and migration of …

Myeloid‐derived suppressor cells (MDSC s) are immature myeloid cells with strong
immunosuppressive activity that promote tumor growth. In this study, we describe a …

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature
myeloid cells that are activated under pathological conditions, such as cancer, or mature …