Integration of whole transcriptome spatial profiling with protein markers
Spatial transcriptomics and proteomics provide complementary information that
independently transformed our understanding of complex biological processes. However …
independently transformed our understanding of complex biological processes. However …
Clonal expansion and epigenetic inheritance of long-lasting NK cell memory
Clonal expansion of cells with somatically diversified receptors and their long-term
maintenance as memory cells is a hallmark of adaptive immunity. Here, we studied …
maintenance as memory cells is a hallmark of adaptive immunity. Here, we studied …
The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments
Neutrophils are implicated in multiple homeostatic and pathological processes, but whether
functional diversity requires discrete neutrophil subsets is not known. Here, we apply single …
functional diversity requires discrete neutrophil subsets is not known. Here, we apply single …
[HTML][HTML] Tissue-specific abundance of interferon-gamma drives regulatory T cells to restrain DC1-mediated priming of cytotoxic T cells against lung cancer
Local environmental factors influence CD8+ T cell priming in lymph nodes (LNs). Here, we
sought to understand how factors unique to the tumor-draining mediastinal LN (mLN) impact …
sought to understand how factors unique to the tumor-draining mediastinal LN (mLN) impact …
Broad immune activation underlies shared set point signatures for vaccine responsiveness in healthy individuals and disease activity in patients with lupus
Responses to vaccination and to diseases vary widely across individuals, which may be
partly due to baseline immune variations. Identifying such baseline predictors of immune …
partly due to baseline immune variations. Identifying such baseline predictors of immune …
Normalizing and denoising protein expression data from droplet-based single cell profiling
MP Mulè, AJ Martins, JS Tsang - Nature communications, 2022 - nature.com
Multimodal single-cell profiling methods that measure protein expression with oligo-
conjugated antibodies hold promise for comprehensive dissection of cellular heterogeneity …
conjugated antibodies hold promise for comprehensive dissection of cellular heterogeneity …
Integrated scRNA-Seq identifies human postnatal thymus seeding progenitors and regulatory dynamics of differentiating immature thymocytes
During postnatal life, thymopoiesis depends on the continuous colonization of the thymus by
bone-marrow-derived hematopoietic progenitors that migrate through the bloodstream. The …
bone-marrow-derived hematopoietic progenitors that migrate through the bloodstream. The …
Prostaglandin E2 controls the metabolic adaptation of T cells to the intestinal microenvironment
Immune cells must adapt to different environments during the course of an immune
response. Here we study the adaptation of CD8+ T cells to the intestinal microenvironment …
response. Here we study the adaptation of CD8+ T cells to the intestinal microenvironment …
Early cellular mechanisms of type I interferon-driven susceptibility to tuberculosis
Summary Mycobacterium tuberculosis (Mtb) causes 1.6 million deaths annually. Active
tuberculosis correlates with a neutrophil-driven type I interferon (IFN) signature, but the …
tuberculosis correlates with a neutrophil-driven type I interferon (IFN) signature, but the …
Age-associated B cells predict impaired humoral immunity after COVID-19 vaccination in patients receiving immune checkpoint blockade
Age-associated B cells (ABC) accumulate with age and in individuals with different
immunological disorders, including cancer patients treated with immune checkpoint …
immunological disorders, including cancer patients treated with immune checkpoint …