Testing the causal relationships of physical activity and sedentary behaviour with mental health and substance use disorders: a Mendelian randomisation study
Observational studies suggest that physical activity can reduce the risk of mental health and
substance use disorders. However, it is unclear whether this relationship is causal or …
substance use disorders. However, it is unclear whether this relationship is causal or …
Distinct pathway-based effects of blood pressure and body mass index on cardiovascular traits: comparison of novel Mendelian Randomization approaches
Background Mendelian randomization (MR) leverages genetic variants as instrumental
variables to determine causal relationships in epidemiology. However, challenges persist …
variables to determine causal relationships in epidemiology. However, challenges persist …
MR-link-2: pleiotropy robust cis Mendelian randomization validated in four independent gold-standard datasets of causality
A van der Graaf, R Warmerdam, CMP Auwerx… - medRxiv, 2024 - medrxiv.org
Mendelian randomization (MR) can identify causal relationships from observational data but
has increased Type 1 error rates (T1E) when genetic instruments are limited to a single …
has increased Type 1 error rates (T1E) when genetic instruments are limited to a single …