The past decade has witnessed a rapid growth in understanding of the pivotal roles of
mechanical stresses and physical forces in cell biology. As a result, an integrated view of …

Endocytosis allows cells to transport particles and molecules across the plasma membrane.
In addition, it is involved in the termination of signalling through receptor downmodulation …

Plasticity of cancer invasion and metastasis depends on the ability of cancer cells to switch
between collective and single-cell dissemination, controlled by cadherin-mediated cell–cell …

Just as in clay moulding or glass blowing, physically sculpting biological structures requires
the constituent material to locally flow like a fluid while maintaining overall mechanical …

Pathological morphological changes in tumor tissue enable collective cancer cell
unjamming, a cellular motility transition. However, fundamental questions remain: Is …

The epithelial-to-mesenchymal transition (EMT) and the unjamming transition (UJT) each
comprises a gateway to cellular migration, plasticity and remodeling, but the extent to which …

Tissue, cell, and nucleus morphology change during tumor progression. In 2D confluent cell
cultures, different tissue states, such as fluid (unjammed) and solid (jammed), are correlated …

The physical state of embryonic tissues emerges from non-equilibrium, collective
interactions among constituent cells. Cellular jamming, rigidity transitions and characteristics …

Embryo development requires biochemical signalling to generate patterns of cell fates and
active mechanical forces to drive tissue shape changes. However, how these processes are …

The 3D architecture of tissues bearing tumors impacts on the mechanical microenvironment
of cancer, the accessibility of stromal cells, and the routes of invasion. A myriad of intrinsic …